Analgesics

Question 1

Effects of paracetamol overdose

Answer 1

Hepatotoxicity, metabolic acidosis

Question 2

AEs of paracetamol

Answer 2

Rash, fever, warfarin interaction (increases INR)

Question 3

Example of selective COX-2 inhibitor

Answer 3

Celecoxib

Question 4

AEs of NSAIDs - cardiovascular, GI, renal

Answer 4

Cardiovascular - fluid retention, MI, stroke, hypertension
GI - peptic ulcers
Renal - renal impairment

Question 5

Examples of weak opioids

Answer 5

Codeine, dihydrocodeine, tramadol

Question 6

Examples of strong opioids

Answer 6

Morphine, oxycodone, buprenorphine, fentanyl, hydromorphone

Question 7

AEs of opioids - cardiovascular, respiratory, GI, renal, neurological, dermatological

Answer 7

Cardiovascular - bradycardia, hypotension
Respiratory - respiratory depression, apnoea
GI - nausea/vomiting, anorexia, gastric dysmotility, constipation
Renal - urinary retention
Neurological - confusion, delirium, sedation, dysphoria, euphoria, miosis, impaired cognition
Dermatological - sweating, flushing, urticaria, pruritus