Diabetes drugs Flashcards
1
Q
metformin MOA
A
inhibit mitochondrial glycerol-3-phosphate dehydrogenase
inhibits glucogenogenesis and action of glucagon
2
Q
Sulfonylurea MOA
A
closes K+ channel
opens Ca2+ channel
increased Ca2+ leads to insulin release
3
Q
GLP-1 MOA (3)
A
decrease glucagon release
increase insulin postprandial
slow gastric emptying
4
Q
SGLT2 inhibitors
A
promotes renal excretion of glucose by blocking reabsorption of glucose in the PCT
5
Q
Which drugs can lead to hypoglycemia?
A
sulfonylureas
meglinitides
6
Q
What can lead to UTIs?
A
SGLT2 inhibitors
7
Q
What can lead to lactic acidosis?
A
metformin
8
Q
What can lead to acute pancreatitis?
A
GLP-1
9
Q
Which drugs can have weight loss and CV / renal benefit ?
A
SGLT2 inhibitors
GLP-1
10
Q
What drugs can cause weight gain?
A
sulfonylureas, meglitinides, thiazolidiniones (-zone)
