Diabetes Flashcards
What things are diabetes the leading cause of?
Non-traumatic amputations, blindness, end stage kidney disease
What does diabetes have a high rate of?
Cardiovascular disease, stroke, peripheral vascular disease
Deficiency of insulin production or usage. Results in hyperglycemia. Requires a lot of self-care management.
Diabetes mellitus
Area of a lot of research. Endocrinologist.
What is the pancreas made up of?
Pancreatic acini cells and islets of langerhans. Each islet consists of beta and alpha cells
Regulates glucose metabolism and stimulates glucose uptake. Promotes the conversion of glucose to carbohydrate glycogen.
Beta cells
Opposes the action of insulin. Stimulates the liver to break down glycogen and amino acids.
Glucagon produced by alpha cells
What two things can insulin deficiency be?
Can be absolute or relative
Explain the pathophysiology of diabetes?
Insulin deficiency. Glucose builds up in the blood case it cannot get into cells to be used. Leads to increased glucose levels and impaired fat metabolism. Cells end up metabolizing their own glycogen supply and breaking down protein to produce the needed engird. This alters triglycerides, fatty acid, and glycerol metabolism. Ketone bodies are formed, leading to metabolic acidosis.
What re the risk factors for type 1 diabetes?
Autoimmune disorders, genetics, environmental
What percent of diabetics tend to be type 1? type 2?
5-10% of diabetics
90-95% of diabetics
Usually develops before the age of thirty but may develop any time. Rapid clinical presentation. Little or no insulin available. Lean or normal body build. Weak family history.
Type 1 diabetes. Not so much a genetic disorder but a genetic predisposition. Insulin dependent. Positive for human leukocyte antigens (HLA).
What are the risk factors for type 2 diabetes?
Abdominal obesity. Hyperglycemia. HTN. Hyperlipidemia.
Usually occurs after age 30 and obese patients. Slow clinical presentation. Often seen in overweight people and those with a family history of obesity. Lack of physical exercise
Type 2 diabetes. History of gestational diabetes mellitus. The problem is insulin resistance or impaired insulin secretion.
What are the similarities between the two types?
Both greatly increase a person’s risk for a variety of complications. Although monitoring and management can prevent or delay complications, diabetes remains the leading cause of blindness and kidney failure.
Reflects the average blood glucose level over the previous 3 months. Provides objective measure of control.
HgbA1c (Glycosylated hemoglobin). Blood glucose readily attaches to hemoglobin.
Normal non-diabetic: 4-6%
Diabetic: goal below 7%
ADA recommends quarterly checks
HgbA1c blood sugar equivalents?
- 0 = 126
- 0 = 154
- 0 = 183
- 0 = 212
- 0 = 240
- 0 = 269
- 0 = 298
What are some common findings when diagnosing diabetes?
HgbA1c may be elevated. Serum lipids may be elevated. Electrolytes, especially K, will be out of balance.