Dexamethasone Sodium Phosphate Flashcards
Generic Name:
Dexamethasone Sodium Phosphate
Trade Name:
Decardron
Supplied:
10mg/1mL
Class:
Synthetic adrenocoricoid/glucocoricoid with a predominance of glucocorticoid action, anti-inflammatory
Mechanism of Action
Improves lung function and myocardial performance: stabilization of lysosomal and cell membranes, inhibition of compliment-induced granulocyte aggregation, rightward shift in oxygen-hemoglobin dissociation curve, inhibition of prostaglandin and leukotriene production, increase in surfactant production, decrease in pulmonary edema, relaxation of bronchospasm.
Indications and Field Use:
- Reactive airway disease: Acute Exacerbation of bronchial asthma
- Anaphylaxis
- Cerebral edema (non-traumatic)
Contraindications:
- Systemic fungal infections
- Hypersensitivity to any component of dexamethasone, including sulfites
- Preterm infants
Adverse Reactions:
Sodium retention, fluid retention, potassium loss, hypokalemic alkalosis, hypertension, convulsions, hyperglycemia, myocardial rupture following recent myocardial infarction
Incompatibilities/Drug Interactions:
Dexamethasone is not compatible with benadryl or versed in IV tubing.
Adult Dosage: Reactive Airway Disease, Anaphylaxis:
8-24mg
Adult Dosage: Cerebral Edema (non-traumatic):
1-5mg/kg
Pediatric Dosage: Reactive Airway Disease, Anaphylaxis:
0.25-0.5mg/kg
Pediatric Dosage: Cerebral Edema (non-traumatic):
0.5-1.5mg/kg
Routes of Administration:
IV/IO/IM
Onset of Action:
4-8 hours
