Developmental Anomalies Flashcards
Term used when having defects of growth or development of a tissue or organ that are present, but not necessarily obvious at birth
Congenital lesions
What are 2 types of Developmental Anomalies?
1) Anatomical
2) Biochemical
What is the MDx?
Arthrogryposis
(limbs fixed in place)
What is the MDx?
Hydranencephaly
(water in brain)
When affected with Akabane (Bunyavirus), the result…
- Infected 120-180 days -> ?
- Infected 80-100 days –> ?
Infected 120-180 days -> Arthrogryposis
Infected 80-100 days –> Hydranencephaly
What are 6 types of Anatomic Malformations?
1) Failure to fuse
2) Failure to canalize/separate
3) Cysts
4) Failure of a structure to develop
5) Abnormal development of a structure
6) Ectopic development
The nature of the anatomical defect that results depends on? (2 things)
- Timing
- Tissue injured
What are the 3 periods of gestation of when injury can occur and the effects on the embyronal cells?
1) Zygote -> Death and reabsorption
2) Embryo (organogensis) -> depends on extend of injury:
- 1.Developmental anomaly carried to term
- Death of embryo and abortion
3) Fetus (growth) -> Illness/death of fetus
You think a fetal viral infection is the cause…
What is the best approach to confirm?
Serology of calves
MDx: ?
Disease name: ?
Type of Anatomical Defect: ?
(Dog pancreas)
MDx: Pancreatic aplasia
Disease name: Exocrine pancreatic insufficiency
Type of Anatomical Defect: Failure to develop
MDx: ?
Disease name: ?
Type of Anatomical Defect: ?
(dog pancreas)
MDx: Pancreatic hypoplasia
Disease name: Exocrine pancreatic insufficiency
Type of Anatomical Defect: Failure to develop
MDx: ?
Type of Anatomical Defect: ?
(Calf/Puppy)
MDx: Spina Bifida
Type of Anatomical Defect: Failure to fuse
MDx: ?
Type of Anatomical Defect: ?
(calf brain)
MDx: Meningoencephalocele
Type of Anatomical Defect: Failure to fuse
MDx: ?
Type of Anatomical Defect: ?
(calf brain)
MDx: Maxillary brachygnathia and palatoschisis (cleft palate)
Type of Anatomical Defect: Failure to fuse
MDx: ?
Type of Anatomical Defect: ?
(calf)
MDx: Schistosomus reflexus
Type of Anatomical Defect: Failure to fuse
MDx: ?
Type of Anatomical Defect: ?
(lamb)
MDx: atresia ani
Type of Anatomical Defect: Failure to canalize
MDx: ?
Disease name: ?
Type of Anatomical Defect: ?
(cat kidneys)
MDx: Renal cysts
Disease name: Polycystic kidney disease
Type of Anatomical Defect: Cyst
MDx: ?
Disease name: ?
Type of Anatomical Defect: ?
(dog brain)
MDx: Pituitary cyst (Raphke’s puch cyst)
Disease name: Pituitary dwarfism
Type of Anatomical Defect: Cyst
MDx: ?
Disease name: ?
Type of Anatomical Defect: ?
(littermate puppies)
MDx: Proportionate dwarfism
Disease name: Pituitary dwarfism
Type of Anatomical Defect: Cyst
MDx: ?
Type of Anatomical Defect: ?
(calf feet)
MDx: Polydactyly
Type of Anatomical Defect: Abnormal development of a structure
MDx: ?
Type of Anatomical Defect: ?
(sheep thoracic limbs)
MDx: Polymelia
Type of Anatomical Defect: Abnormal development of a structure
MDx: ?
Disease name: ?
Type of Anatomical Defect: ?
(dog coxofemoral joints)
MDx: Coxofemoral malformation
Disease name: Hip dysplasia
Type of Anatomical Defect: Abnormal development of a structure
MDx: ?
Type of Anatomical Defect: ?
(calf heart)
MDx: Ectopia cordis
Type of Anatomical Defect: Ectopic development
What are 4 examples of Biochemical Defects?
1) Haemophilia
2) Lysosomal storage diseases
3) Dermatosporaxis
4) Albinism
