Developing Drugs

Question 1

Drugs must be SAFE

Answer 1

Doesn’t give severe sideffects.

Question 2

Drugs must be EFFECTIVE

Answer 2

must work

Question 3

Drugs must be STABLE

Answer 3

long life, easy to store and use.

Question 4

Drugs must be SUCCESSFULLY ABSORBED AND EXCRETED

Answer 4

Be able to leave the body

Question 5

Drugs must be…..

Answer 5

Safe
Effective
Stable
Absorbed and excreted

Question 6

Pre-clinical testing phase I

Answer 6

Vitro screening - add drug in test tube to work on cells

Question 7

Pre-clinical testing Phase II

Answer 7

Animal testing - tests for safety

Question 8

Clinical trials Phase I

Answer 8

Low doses given to healthy volunteers. Tests for sideffects.

Question 9

Clinical trials Phase II

Answer 9

Low dose given to small number of Patients - test for effectiveness and optimum doses.

Question 10

Clinical trials Phase III

Answer 10

Doses given to larger group of controlled patients through double blind trials and placebo - validity and reliability of data.

Question 11

Double blind

Answer 11

Neither the patient or doctor whether it is the actual drug or a placebo

Question 12

Digitalis (heart drug)

Answer 12

Extracted from Foxgloves. Strengthens heart beat

Question 13

Aspirin (painkiller)

Answer 13

Extracted from Willow bark. Pain and anti-inflammatory properties.

Question 14

Penicillin (antibiotic)

Answer 14

Extracted from Pencillium notatum fungus.