Dermatopharmacology Chapter 2 Flashcards
IL-1 inhibitors?
Canakinumab, Anakinra, Rilonacept, and Gevokizumab
Note: important to monitor absolute neutrophil count as neutropenia can occur.
Imiquimod inceases production of which cytokine?
IFN –alpha
Stimulates IFN-α ➔ ↓TGF-β (note: ↑TGF-β levels are a/w keloid formation) IFN-α ➔ ↑collagen breakdown
What is a collodian preparation?
Cellulose nitrate in organic solvent
Acute febrile neutrophilic dermatosis, Sweet’s, may be caused by which drug?
G-CSF
Culprit drugs in pseudoporphyria?
NSAIDs* (naproxen, piroxicam), nalidixic acid, furosemide, HCTZ, isotretinoin, TCNs, sulfonamides
Photosensitivity drugs?
Griseofulvin, NSAIDs, phenothiazines, sulfonamides, thiazides, dapsone, MTX, hydroxyurea, 5-FU, fluoroquinolones, TCNs, furosemide, diltiazem, isotretinoin, imipramine, chlorpromazine, phenothiazines
Combination of bleomycin and vinblastine can cause?
Raynaud’s phenomenon
Photo-onycholysis drugs?
TCN, OCPs, fluoroquinolones, psoralens
SCLE drugs?
HCTZ, griseofulvin, terbinafine, CCBs.
Versus SLE-causing drugs: hydralazine, procainamide, isoniazid, MCN, phenytoin, penicillamine
Supravenous serpentine hyperpigmentation is caused by?
5-FU
A consistent histopathologic feature of hydroxyurea dermopathy is:
Hydropic degeneration, DM-like
PAS + granules in the outer layer of eccrine ductal cells can be observed in?
Lafora’s disease
Retinoid used to treat Kaposi sarcoma?
a) Tazarotene
b) Bexarotene
c) Acitretin
d) Alitretinoin
d) Alitretinoin
Lived racemes is generally indicative of:
PV
Sneddon’s syn
Cutaneous polyarteritis nodosa
Raynaud’s
Sneddon’s syn
Raindrops on a dusty road appearance is seen in a toxicity to?
Arsenic
Nail psoriasis that reflects exocytosis of leukocytes beneath nail plate?
Oil drop phenomenon
