Dermatopathology Chapter 7 Flashcards
Multiple basaloid tumor micronodules fused together in jigsaw pattern, small ducts, and thick hyaline (pink) BMZ material surrounding each tumor micronodule?
Cylindroma
Lymphocytes “peppered into tumor”?
Spiradenoma
Nodule of monomorphous poroid cells with no epidermal connection?
Dermal duct tumor
Erythema induratum (Bazin disease) is?
Subcutaneous inflammatory nodules with ulceration on posterior calves, Associated with past or active TB
Verhoeff-van Gieson (VVG) stains elastic fibers and collagen?
Elastic fibers - Black
Collagen - Red
Rest of connective tissue - Yellow
Masson Trichrome stains smooth muscle?
Smooth muscle - Red
Collagen fibers -Blue/green
Movat’s pentachrome stains smooth muscle?
Smooth muscle - Red (Same as Masson trichrome)
Elastic fibers - Black
Collagen - Yellow
Smooth muscle stains blue with what stain?
Phosphotungstic acid hematoxylin
Lipids stain red with Oil-Red-O and Scarlet red part from?
Sudan black B, which stains lipid black
What stain distinguishes iron/hemosidrin from melanin?
Prussian blue, stains iron, blue
Von Kossa stains calcium?
Brown/black
and stains calcium red/orange with Alizarin red
Congo red stains amyloid?
Red/pink, apple green birefringence when polarized
Which stains are used for amyloid?
Thioflavin T and cresol violet
Fontant masson and silver nitrate stain for?
Melanin
Clear cell acanthoma and trichilemmoma show positive stain for?
PAS is positive due to increase glycogen in these conditions
PAS-D for diastase is useful for?
Helpful for demonstrating BMZ thickening (lupus, DM) and thickened vessel walls of porphyria
Giemsa stains?
Leishmania, Histoplasma, and Rickettsia
What stain can you use for neurofibroma’s?
Bodian, stains positively black for nerve axons
What stain would highlight elastic fiber changes in PXE?
Verhoefs-Van Gieson
Most serious adverse event with clofazimine?
Crystal deposition in the bowel
Granular layer contains?
Profillagrin
Function of IL-1?
T-lymphocyte chemotaxis
Weibel-Palade bodies are characteristic of?
A. Vascular endothelial cells
B. Keratinocytes
C. Langerhans cells
D. Melanocytes
A. Vascular endothelial cells
Cellular blue nevus histo buzzword?
“dumb-bell configuration”
Neurothecoma stains?
S100A6+, NKI-C3+, and PGP9.5+
“copper pennies” or “Medlar bodies” within granulomatous dermal infiltrate are seen with?
Chromoblastomycosis
Large spherules (up to 80 micro mm) containing smaller endospores?
Coccidioidomycosis
Clear gelatinous capsule, mucicarmine+, surrounding yeast clusters seen with?
Cryptococcus
Acantholytic dyskeratosis, corps ronds, corps grains seen in?
Darier disease
Staining pattern for dermatofibroma?
Factor XIIIa+, stromelysin 3+, CD34-
Opposite is true for Dermatofibrosarcoma is storiform pattern, extensive honeycombing of fat, factor XIIIa–, stromelysin 3–, CD34+
Dermatomyositis has lots or less of mucin?
Abundant dermal mucin
Tight (“coat-sleeve”) lymphocytic perivascular inflammation is histo seen in?
Erythema annulare centrifugum
Glomus tumor stains positive for?
SMA+
Granuloma faciale special histo?
Grenz zone; perivascular mixed inflammation (neutrophils, plasma cells, eosinophils)
“satellite cell necrosis” feature of?
Acute GVHD
“mulberry cells” (white vacuoles w pink borders)
Hibernoma
Spindled myofibroblasts with characteristic perinuclear eosinophilic cytoplasmic inclusion bodies (PTAH+, trichrome+ , SMA+)
Infantile digital fibromatosis
thin “sieve-like” vessels w/ hemorrhage and hemosiderin, conspicuous plasma cells
Kaposi sarcoma
“sawtoothed rete,” seen with?
Lichen planus
“pop bead-like”
Lobomycosis
large CD30+ Reed-Sternberg-like cells
Lymphomatoid papulosis
“Chicken wire” blood vessels in myxoid background?
Myxoid liposarcoma
“buckshot” pattern, and transepidermal elimination of tumor cells; CK7+, CK20- seen in?
Paget’s disease, extramammary PD
“mariner’s wheel” seen in?
Paracoccidioidomycosis
“ghost cells” seen with?
Pancreatic fat necrosis
Pilomatricoma
Multinucleated floret cells, “flower-like” arrangement of nuclei?
Pleomorphic lipoma
PLEVA histo?
Parakeratosis
Lichenoid interface
Extravasated blood
V-shaped (“wedge”) dermal lymphocytic infiltrate
Acute epidermal changes, spongiosis +/– ulceration
Dermatofibroma
Interstitial spindle cell proliferation in “curlicue pattern,” collagen trapping, epidermal/follicular induction, hemosiderin-laden histiocytes/Touton-like GCs, Factor XIIIa+ and CD34-
Dirty necrosis
Metastatic colon adenocarcinoma
Anastomosing tumor islands with eccrine differentiation that demonstrate multiple foci of attachment to the epidermis.
Poroma
Multiple nests of basaloid cells, some showing abortive hair follicle differentiation
Trichoepithelioma
Sebaceous glands in cyst wall, eosinosphilic cuticle, “sharktooth” lining, represents?
Steatocytoma
