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AliKhan Derm > Dermatopathology Chapter 7 > Flashcards

Dermatopathology Chapter 7 Flashcards

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Dermatology Board Prep flashcards
1
Q

Multiple basaloid tumor micronodules fused together in jigsaw pattern, small ducts, and thick hyaline (pink) BMZ material surrounding each tumor micronodule?

A

Cylindroma

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2
Q

Lymphocytes “peppered into tumor”?

A

Spiradenoma

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3
Q

Nodule of monomorphous poroid cells with no epidermal connection?

A

Dermal duct tumor

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4
Q

Erythema induratum (Bazin disease) is?

A

Subcutaneous inflammatory nodules with ulceration on posterior calves, Associated with past or active TB

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5
Q

Verhoeff-van Gieson (VVG) stains elastic fibers and collagen?

A

Elastic fibers - Black
Collagen - Red
Rest of connective tissue - Yellow

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6
Q

Masson Trichrome stains smooth muscle?

A

Smooth muscle - Red
Collagen fibers -Blue/green

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7
Q

Movat’s pentachrome stains smooth muscle?

A

Smooth muscle - Red (Same as Masson trichrome)
Elastic fibers - Black
Collagen - Yellow

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8
Q

Smooth muscle stains blue with what stain?

A

Phosphotungstic acid hematoxylin

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9
Q

Lipids stain red with Oil-Red-O and Scarlet red part from?

A

Sudan black B, which stains lipid black

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10
Q

What stain distinguishes iron/hemosidrin from melanin?

A

Prussian blue, stains iron, blue

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11
Q

Von Kossa stains calcium?

A

Brown/black
and stains calcium red/orange with Alizarin red

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12
Q

Congo red stains amyloid?

A

Red/pink, apple green birefringence when polarized

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13
Q

Which stains are used for amyloid?

A

Thioflavin T and cresol violet

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14
Q

Fontant masson and silver nitrate stain for?

A

Melanin

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15
Q

Clear cell acanthoma and trichilemmoma show positive stain for?

A

PAS is positive due to increase glycogen in these conditions

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16
Q

PAS-D for diastase is useful for?

A

Helpful for demonstrating BMZ thickening (lupus, DM) and thickened vessel walls of porphyria

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17
Q

Giemsa stains?

A

Leishmania, Histoplasma, and Rickettsia

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18
Q

What stain can you use for neurofibroma’s?

A

Bodian, stains positively black for nerve axons

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19
Q

What stain would highlight elastic fiber changes in PXE?

A

Verhoefs-Van Gieson

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20
Q

Most serious adverse event with clofazimine?

A

Crystal deposition in the bowel

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21
Q

Granular layer contains?

A

Profillagrin

22
Q

Function of IL-1?

A

T-lymphocyte chemotaxis

23
Q

Weibel-Palade bodies are characteristic of?
A. Vascular endothelial cells
B. Keratinocytes
C. Langerhans cells
D. Melanocytes

A

A. Vascular endothelial cells

24
Q

Cellular blue nevus histo buzzword?

A

“dumb-bell configuration”

25
Q

Neurothecoma stains?

A

S100A6+, NKI-C3+, and PGP9.5+

26
Q

“copper pennies” or “Medlar bodies” within granulomatous dermal infiltrate are seen with?

A

Chromoblastomycosis

27
Q

Large spherules (up to 80 micro mm) containing smaller endospores?

A

Coccidioidomycosis

28
Q

Clear gelatinous capsule, mucicarmine+, surrounding yeast clusters seen with?

A

Cryptococcus

29
Q

Acantholytic dyskeratosis, corps ronds, corps grains seen in?

A

Darier disease

30
Q

Staining pattern for dermatofibroma?

A

Factor XIIIa+, stromelysin 3+, CD34-

Opposite is true for Dermatofibrosarcoma is storiform pattern, extensive honeycombing of fat, factor XIIIa–, stromelysin 3–, CD34+

31
Q

Dermatomyositis has lots or less of mucin?

A

Abundant dermal mucin

32
Q

Tight (“coat-sleeve”) lymphocytic perivascular inflammation is histo seen in?

A

Erythema annulare centrifugum

33
Q

Glomus tumor stains positive for?

A

SMA+

34
Q

Granuloma faciale special histo?

A

Grenz zone; perivascular mixed inflammation (neutrophils, plasma cells, eosinophils)

35
Q

“satellite cell necrosis” feature of?

A

Acute GVHD

36
Q

“mulberry cells” (white vacuoles w pink borders)

A

Hibernoma

37
Q

Spindled myofibroblasts with characteristic perinuclear eosinophilic cytoplasmic inclusion bodies (PTAH+, trichrome+ , SMA+)

A

Infantile digital fibromatosis

38
Q

thin “sieve-like” vessels w/ hemorrhage and hemosiderin, conspicuous plasma cells

A

Kaposi sarcoma

39
Q

“sawtoothed rete,” seen with?

A

Lichen planus

40
Q

“pop bead-like”

A

Lobomycosis

41
Q

large CD30+ Reed-Sternberg-like cells

A

Lymphomatoid papulosis

42
Q

“Chicken wire” blood vessels in myxoid background?

A

Myxoid liposarcoma

43
Q

“buckshot” pattern, and transepidermal elimination of tumor cells; CK7+, CK20- seen in?

A

Paget’s disease, extramammary PD

44
Q

“mariner’s wheel” seen in?

A

Paracoccidioidomycosis

45
Q

“ghost cells” seen with?

A

Pancreatic fat necrosis
Pilomatricoma

46
Q

Multinucleated floret cells, “flower-like” arrangement of nuclei?

A

Pleomorphic lipoma

47
Q

PLEVA histo?

A

Parakeratosis
Lichenoid interface
Extravasated blood
V-shaped (“wedge”) dermal lymphocytic infiltrate
Acute epidermal changes, spongiosis +/– ulceration

48
Q
A

Dermatofibroma
Interstitial spindle cell proliferation in “curlicue pattern,” collagen trapping, epidermal/follicular induction, hemosiderin-laden histiocytes/Touton-like GCs, Factor XIIIa+ and CD34-

49
Q

Dirty necrosis

A

Metastatic colon adenocarcinoma

50
Q

Anastomosing tumor islands with eccrine differentiation that demonstrate multiple foci of attachment to the epidermis.

A

Poroma

51
Q

Multiple nests of basaloid cells, some showing abortive hair follicle differentiation

A

Trichoepithelioma

52
Q

Sebaceous glands in cyst wall, eosinosphilic cuticle, “sharktooth” lining, represents?

A

Steatocytoma

AliKhan Derm (13 decks)

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