Basic science Chapter 1 Flashcards
1
Q
When do Melanocytes, Langerhans cells, Merkel cells, Melanocyte migration guided by KIT/KIT ligand occur in embryogenesis?
A
9–12 weeks
+ eyebrows
+ scalp follicles
2
Q
At 12 weeks in embryology?
A
Proximal nail folds form
Nail plate forms at 17 weeks
3
Q
Melanin production begins at?
A
12–18 weeks
4
Q
Examples of cutaneous disease with variable expression?
A
Darier’s disease and NF1 have broad range of severity
5
Q
UV light bands?
A
UVC - 200–280 nm
UVB - 280–320 nm
UVAII - 320– 340 nm
UVAI - 340–400 nm
6
Q
IL-36 receptor antibody?
A
Spesolimab in an IL-36 receptor antibody used in pustular psoriasis
7
Q
Mutations a/w vitiligo?
A
NLRP1
8
Q
Defects in lysosome and melanosome trafficking to dendrites result in?
A
Griscelli (MYO5A, RAB27A, and MLPH mutations) and Chédiak-Higashi syndrome (LYST mutations)
