Dermatology2 Flashcards
What is the prophylaxis for influenza?
Oseltamivir (Tamifulu), Zanamivir (Relenza) and Peramivir (neuromindase inhibitor)
When should antivirals be given for influenza?
within 48hrs
What is the recommendation for vaccine for influenza?
everyone > 6mo
When is the influenza season?
Nov- March
C/I for influenza vaccine?
egg allergy, previous rxn to vaccine, developed Guillain Barre syndrome, have had GBS in past 6ks, <6mo
What are the symptoms of flu?
abrupt fever, chills, malaise, muscle aches, sore throat, headache, coryza
What defines AIDS?
CD4 count of <200 cells
What screening test is used for HIV?
ELISA
What test confirms HIV?
Western blot
What is the txt for HIV?
HAART
When should PEP be started for HIV?
within 72hrs of exposure
How is HIV transmitted?
semen, blood, vaginal secretions breast milk
Erythema migrans is seen in what disease?
Lyme disease
What is the treatment for lyme disease?
Doxycycline
What is the prophylactic for lyme disease?
Doxycycline
What are the 3 stages of lyme disease?
early localized, early disseminated, late disease
Diagnosis lyme disease?
ELISA followed by Western blot to confirm
What is the txt of lyme disease in children and preggo?
Amoxicillin or cefuroxime
What is the classic triad of meningitis?
fever greater than 38
nuchal rigidity
headache
Knee extension causes pain neck?
Kernig’s sign
Leg raise when bend neck?
Brudzinski’s sign
What is seen in babies with suspected meningitis?
bulging fontanelle
What are the two types of meningitis?
aseptic and bacterial
What is the most common cause of aseptic meningitis?
Enterovirus
What is the most common cause of bacterial meningitis?
S. pneumoniae
Evidence of meningitis but negative blood cultures indicates?
Aseptic meningitis
Gram negative diplococci?
N. meningitidis
MC cause of neonate meningitis?
E. coli and S. agalactiae
MC cause of >60 or immunocomprised meningitides?
Listeria or cryptococcus neoformans
Dx of meningitis?
lumbar puncture
CSF finding for bacterial meningitis?
Increase protein
decreased glucose
markedly increased opening pressure
CSF finding for viral meningitis?
normal pressure increased WBC (lymphocytes)
CSF finding for Guillain Barre Syndrome?
increased protein
normal glucose
Household contacts of pts with bacterial meningitis are treated with?
Ciprofloxacin, Rifampin, Levaquin, Zithromax, Rocephin
What is the treatment for bacterial meningitis?
Dexamethasone + empiric IV abx (cephalosporin, vancomycin, pencillins)
What is the treatment for viral meningitis?
symptomatic or IV acyclovir for HSV
What is seen in dx of mono?
atypical lymphocytosis
A Pencillin given in mono can cause what?
maculopapular rash
Classic triad of mono?
fever
lymphadenopathy
pharyngitis
How is mono transmitted?
oropharyngeal secretions and salvia
The kissing disease
Epstein Barr virus
Pts with mono are at risk of what?
splenic rupture
How is Epstein Barr virus diagnosed?
“monospot”
What is a monospot?
mononucleosis rapid slide agglutination test for heterophile antibodies
What antibodies are seen in mono?
heterophile antibodies
Treatment for Mono?
Supportive
Can a patient contract mono again after exposure?
nope!
Rose spots is seen in?
Enteric fever (salmonella typhi)
Pea soup diarrhea is seen in?
Enteric fever (typhoid)
infected egg yolks?
Gastroenteritis (salmonella typhimurium, Enteritidis)
How is salmonella treated?
Cefriaxone, fluoroquinolones, azithromycin
Fever increases with “pea soup” diarrhea followed by pink papules on the trunk, which fades when pressure is applied
Salmonella typhi
The most common form of salmonella infection?
gastroenteritis
What is the treatment for gastroenteritis?
self-limited, symptomatic
What symptoms are seen in gastroenteritis?
mucus+ bloody diarrhea vomiting abdominal pain fever cramping
Diarrhea from poultry products- dairy, meat, eggs, exotic pets (reptiles, turtles)
salmonell
What are symptoms of typhoid?
headache, pea soup stools (brown-green), intractable fever, bradycardia, rose spots
Diarrhea from undercooked ground beef, unpasteurized milk/ apple cider, day care centers, contaminated water
enterohemorrhagic ecoli 0157:H7
Treatment for enterohemorrhagic ecoli?
fluid replacement and supportive
Abx use in enterohemorrhagic e.coli can cause what?
hemolytic uremic syndrome
What are symptoms of enterohemorrhagic e.coli?
water diarrhea -> bloody, crampy abdominal pain, vomiting. Fever low grade
Rice water stools?
Vibrio cholerea
What is the MC cause of traveler’s diarrhea?
Enterotoxigenic e.coli
What are the symptoms of enterotoxigenic e.coli?
abrupt onset of watery diarrhea, abdominal cramping, vomiting
Lower abdominal pain, explosive watery diarrhea, mucus blood
Shigella
MC strain of shigella in US?
S. sonnei
What diarrhea can cause reactive arthritis and febrile seizure in children?
Shigella
Whom does Shigella predominately affect?
children (daycares)
treatment for Shigella?
ciprofloxacin
What is the diagnosis of Shigella?
leukocytes and red blood cell on stool culture
Transmitted by drinking unsanitary water/ice
enterotoxigenic e.coli (traveller diarrhea)
What can cause osteomyelitis in the sickle cell patient?
Salmonella
Salad bar diarrhea?
Shigella
How is cryptococcus neoformans meningitis diagnosed?
india ink stain
A rash present with meningitis indicates?
Neisseria meningitidis
multiple well demarcated red/purple infiltrative firm nodules and plaques in pt with a history of HIV
Kaposi sarcoma
What virus causes Kaposi sarcoma?
Human Herpes Virus 8 (HHV8)
AIDS defining cancer?
Kaposi sarcoma
Dx of Kaposi sarcoma?
biopsy- spindle cells mixed w/ vascular tissue
What is the txt for Kaposi sarcoma?
Chemotherapy or radiation
Prognosis of melanoma is most strongly associated with what dimension?
depth of lesion
The most common histologic type of melanoma?
Superficial spreading malignant melanoma
What type of melanoma is seen on the palms, soles, and nail beds?
acral lentiginous melanomas
Txt for Melanoma?
wide excision I-III, IV- chemo
Asymmetric, elevated, blue-tinged lesion with irregular scalloped borders
melanoma
large pruritic, subepidermal bullae in a 75y/o
Bullous pemphigoid
chronic acquired autoimmune subepidermal blistering skin disorder
Bullous pemphigoid
What is the mechanism of bullous pemphigoid?
IgG produced against the basement membrane
Whom does bullous pemphigoid usually affect?
60-80yr old, increases with age
Dx of bullous pemphigoid?
biopsy w/ immunofluorescence - IgG and C3 basement membrane
Txt for bullous pemphigoid?
Topical Corticosteriods, Prednisone, Azathioprine
Nikolsky sign negative in what disease?
Bullous pemphigoid
What are the 3 main pathogens seen in cellulitis?
H. influenzae, Streptococcus, Staphylococcus
Red hot, swollen, tender, fever, and chills
cellulitis
What is the txt for mild cellulitis (MSSA)?
Cephalexin or Dicloxacilln
What is the txt for MRSA?
TMP-SMZ, clindamycin, doxycyline
What is the treatment for a cat bite?
Augmentin or Doxy
Txt for a puncture wound through the shoe?
Ciprofloxacin (Pseudomonas)
raised cauliflower like lesions in clusters on shaft of penis
condyloma acuminatum
What HSV strains cause genital warts?
6 and 11
what vaccine is approved for HPV?
Gardasil 9
How is condyloma acuminatum dx?
NAAT, colposcopy, anoscopy
What is the txt for condyloma acuminatum?
Imiquimod (Aldara), Podofilow, Cryotherapy, surgery or TCA (trichloroacetic acid)
T/F HPV vaccine treats a existing infection
False
When should the HPV vaccine be given?
before the start of sexual activity (age 11-12)
Breakout from nickel, poison ivy?
Allergic dermatitis
Breakout from diaper, cleaners, solvents, detergents, urine, feces
irritant
pruritic lesions, lichenification mostly on the flexor creases
atopic dermatitis
What type of reaction is atopic dermatitis?
IgE, Type I
Coin shaped disc shaped skin lesion?
nummular eczema
Erythematous, yellowish greasy scales, crusted lesions
seborrheic dermatitis
What is the txt for seborrheic dermatitis?
Antifungal shampoo
topical corticosteriod
olive oil compresses
Young woman. Papulopustular, plaques, and scales around the mouth
Perioral dermatitis
What type of reaction is allergic dermatitis
Type IV
What is the dx for dermatitis?
patch test
Pts with atopic dermatitis usually have?
asthma or allergic rhinitis
The “itch that rashes”
atopic dermatitis
Txt for atopic dermatitis?
topical cortiocosteriods
Txt for perioral dermatitis?
topical metronidazole, erythromycin
What is C/I txt in perioral dermatitis?
topical steroids- cause flare of lesions
What is the most common adverse drug reaction?
Skin reactions
What dosage of epinephrine is used for acute txt of anaphylaxis?
02-0.5 mg
What is the txt for drug eruption?
withdrawal offending drug
epi, prednisone-prevent recurrence
urticaria- 2nd gen anthistamine
acute onset of vesicles without erythema on the lateral aspects of fingers, palm, and feet
dyshidrosis