Cardiovascular Flashcards
What is the best initital test for all forms of chest pain?
ECG
Q waves are consistent with what?
a prior MI
What is used to confirm the diagnosis of angina?
stress test
How is ischemia detected on a stress test?
ST segment depression > 2mm
+/- T wave
If a patient has a positive stress test what’s next?
cardiac catheterization
What test is more sensitive in detecting ischemia?
exercise stress echocardiography
Stress test is C/I in who?
unstable angina , MI, aortic dissection , aortic stenosis, uncontrolled HTN, ventricular arrhythmias
How do you diagnosis stable angina pectoris?
positive stress test
perfusion scintigraphy testing
What is the txt for stable angina?
beta blockers, ACEI, statins, aspirin, CCB, coronary angioplasty, coronary artery bypass graft surgery
How many times can sublingual nitroglycerin be admin?
q 5mins up to 3x
What is the definitive procedure for angina?
coronary angiography
What medication is used for immediate relief of acute angina?
nitroglycerin
What is the 1st line therapy for angina?
b blockers
If a pt can’t take a beta blocker for their angina what’s the alternative?
CCB
Metabolic Syndrome
abdominal obesity, triglycerides > 150, HDL <40 men, <50 women, fasting glucose >110 and HTN
What drug is associated with MI?
cocaine
What is the #1 risk factor for MI?
Smoking
Angina w/wo ST elevation, but normal artery
Prinzmental variant angina
How is prinzmetal’s angina diagnosed?
ECG at time of attack
How does prinzmetal’s angina look on ECG?
ST elevation
What is the txt for prinzmetal angina?
CCB
What is C/I in Prinzmetal angina?
beta blockers
What is the best test for diagnosing CHF?
Echocardiogram
What is the gold standard for diagnosing right heart failure?
right heart cardiac catherization
What lab is elevated in CHF?
BNP
What is the treatment of systolic left heart failure?
ACEI + Beta blocker + Loop Diuretic
What is the txt for diastolic heart failure?
ACEI + B blocker or CCB
What are the 3 beta-1 selective used for CHF?
Bisoprolol
Carvedilol
Metoprolol succinate
What is a feature of systolic heart failure?
S3
What does S3 mean?
rapid ventricular filling during early diastole
What feature is diastolic heart failure?
S4
What drug should NEVER be used for diastolic CHF?
Digoxin
What is the most common cause of right heart failure?
left heart failure
Left sided heart failure is characterized by?
pulmonary congestion, exertional dyspnea and cough, fatigue, orthopnea, basilar rales, nocturnal dyspnea
Right sided heart failure due to chronic lung disease?
Cor pulmonale
What is Dressler syndrome?
pericarditis, fever, leukocytosis, and pericardial or pleural effusion occurring 1-2 weeks after MI
Two complications of pericarditis?
pericardial effusion and cardiac tamponade
Chest pain that is worse when supine and during inspiration and alleviated when leaning forward
pericarditis
When is pericardial friction rub best heard?
upright and leaning forward
What is Dressler’s syndrome?
pericarditis 2-5 days after an acute MI
MC viral cause of pericarditis?
Coxsackievirus
What does EKG show for pericarditis?
diffuse, ST segment elevations in the precordial leads
What is Kussmaul’s sign?
an increase rather than normal decrease in CVP during inspiration
Txt of pericarditis?
txt the underlying disease
NSAIDs
Txt of pericardial effusion?
pericardiocentesis
What causes uremic pericarditis?
effect of untreated kidney disease
Define primary hypertension?
> 130/80 on two readings at two separate visits with NO identifiable cause
stage 1 hypertension?
130-139/ 80-89
stage 2 hypertension?
> 140/90
What is seen on fundoscopic exam for a pt with hypertension?
arteriovenous nicking
Txt for most hypertension also those w/ diabetes?
Ace or CCB or Thiazide diuretic
Txt for stage 2 HTN?
2 hypertensive meds
Txt for black adults w/ hypertension?
Thiazide and CCB
SDE of acei
cough, hyperkalemia, C/I preggo
Sde of spironolactone?
hyperkalemia
Beta blockers are C/I in?
Asthma
What does alpha blockers txt?
HTN and BPH
sde of CCB?
leg edema
sde of hydralazine?
lupus like syndrome and pericarditis
Acute rebound hypertensive episode have been reported to occur with the sudden withdrawal of?
Clonidine
sde of thiazide?
hypokalemia
MC cause of secondary hypertension?
Primary aldosteronism
In a hypertensive emergency, blood pressure must be reduced in ?
1 hr
Bp of a hypertensive emergency?
> 180/ > 120
What is a hypertensive emergency
bp >180/>120 with end-stage organ damage
What is a hypertensive urgency?
bp >180/>120 WITHOUT target end organ damage
What is malignant HTN?
diastolic > 120 associated w/ papilledema and either encephalopathy or nephropathy
Consequence of untreated malignant HTN?
progressive renal failure
What drug can cause malignant htn?
MAOI
DOC for hypertensive emergency?
sodium nitroprusside
DOC for hypertensive urgency?
Clonidine
DOC for malignant htn?
hydralazine
Sde of sodium nitroprusside?
cyanide toxicity
antidote for cyanide toxicity caused by sodium nitroprusside?
sodium thiosulfate
Which hyperlipidemia medication cause flushing?
Niacin
Severe hypertriglyceridemia >500 causes?
pancreatitis
eruptive xanthomas
lipemia retinalis
Xanthomas are seen in?
hyperlipidemia
Guidelines for fasting lipid panel on asymptomatic pts?
q 5 yrs
Txt for hyperlipidemia?
statins, fibrates, niacin, fish oil
Sde of statin?
myopathy, rhabdomyolysis
What drug is used for the txt of isolated hypertriglyceridemia
gemfibrozil
What is is endocarditis?
infection of the endocardium
What causes acute bacterial endocarditis?
S. aureus
What causes subacute bacteral endocarditis?
Strep viridans
What causes endocarditis in IV drug users?
Staph aureus
What causes prosthetic valve endocarditis?
Staph epidermidis
Large vegetations in endocarditis is caused by?
Candida
What is the txt for large vegetations in endocarditis?
Amp B
MC cause of endocarditis?
Strep viridans
What pathonogemics are seen in endocarditis?
Splinter hemorrhages
Osler nodes- painful lesions
Roth spots
Janeway lesions
Dx of endocarditis?
Blood cultures- before abx 3sets- 1hr apart
Transesophageal echocardiogram
What is the gold standard for dx endocarditis?
Transesophageal echocardiogram
Whom should receive prophylactic for endocarditis prior to dental procedure?
prosthetic heart valves hx of endocarditis unrepaired cyanosis heart disease congenital heart disease repaired w/ prosthetic device heart valve dx after heart transplant
Txt for native valve endocarditis?
IV ampicillin plus nafcillin + gentamicin
Txt for prosthetic valve endocarditis?
vancomycin + gentamicin + raifampin
Txt for IV drug user endocarditis?
IV nafcillin
Txt for pcn allergic pts with endocarditis?
vancomycin, clindamycin, cephalexin, azithromycin
What is the abx prophylaxis for endocarditis?
2g of Amoxicillin 30-60 before procedure
Which valve is affected with IV drug users w/ endocarditis?
Tricuspid
What are Osler nodes?
PAINFUL, violaceous raised lesions of the fingers, toes, or feet
What are Janeway lesoins?
PAINLESS, red lesions of the palms or soles
What are Roth spots?
exudative lesions in the retina
What criteria is used to establish endocarditis?
Duke
Initial txt for pt with suspected endocarditis?
Vancomycin + cefepime
What should be routinely check with statins?
CMK and LFTs
1S Line thx for triglycerides?
Fibrates gemfibrozil
What is the 2nd line txt for triglycerides?
Niacin
High levels of triglycerides increase the chance of?
acute pancreatitis