Dermatology Therapeutics

Question 1

what are some percutaneous absorption variables for drugs?

Answer 1

• concentration
• lipophilicity
• molecular size

Question 2

most effective topical meds have a MW of what?

Answer 2

<1,000

Question 3

what are some percutaneous absorption variables for vehicles of drugs?

Answer 3

• lipid content

- irritancy

Question 4

what risk of systemic toxicity do you have with corticosteroids?

Answer 4

altered HPA axis

Question 5

what risk of systemic toxicity do you have with silver products?

Answer 5

renal or hepatic problems

Question 6

what risk of systemic toxicity do you have with antibiotics?

Answer 6

GI effects, renal effects

Question 7

what dermatologic vehicles would you use for wounds in the acute inflammatory stage?

Answer 7

wet dressing

powders, lotions, aerosols, sprays

Question 8

what dermatologic vehicles would you use for wounds in the chronic inflammatory stage?

Answer 8

creams

ointments

Question 9

list in order of decerasing potency for various vehicles.

Answer 9

ointment- most potent
gel
cream
lotion- least potent

Question 10

which vehicles should b avoided on fissures and erosions?

Answer 10

gel

lotion

Question 11

name in order of decreasing potency for topical antibiotics.

Answer 11

1. butenafine (Mentax)= terbinefine (Lamasil)
2. Ciclopirox (Loprox)
3. naftifine (Naftin)
4. azoles

Question 12

what effect does propylene glycol have in anti-fungals?

Answer 12

increases penetration

can cause irritation though

Question 13

what are absolute contraindications to corticosteroids?

Answer 13

hypersenstiivity to topical corticosteroid or vehicle

Question 14

what are relative contraindications to corticosteroids?

Answer 14

• bacterial, fungal, or viral infection

- ulceration

Question 15

what percentage of topical corticosteroids is absorbed on normal skin?

Answer 15

1%

Question 16

how does placing topical corticosteroids affect absorption when placing it under occlusion?

Answer 16

increases absorption b increases skin suface area by 40%

Question 17

what TCS should you pick?

Answer 17

effective but least potent

or quickly taper down

Question 18

which topical antiseptic is used for presurgical scrub for surgeon and/or patient?

Answer 18

Clorhexidine

Povidone-Iodine

Question 19

wht is the most common ingredient in OTC abx soap?

Answer 19

triclosan

Question 20

which antifungals are fungistatic? which are fungicidal?

Answer 20

azoles- are fungistatic

allylamines- are fungicidal

Question 21

which antifungal group is effective against dermatophytes?

Answer 21

azoles

Question 22

which antifungal drug is effective against tinea pedis?

Answer 22

terbinafine

Question 23

List the anti-fungal in order of decreasing anti-dermatophyte potency.

Answer 23

Butenafine (Mentax)= Terminafine (Lamasil) * most potent
Ciclopirox (Loprox)
Naftifine (Naftine)
Azoles

Question 24

what vehicle is used in some antifungals to increase penetration?

Answer 24

propylene glycol