Dermatology - skin and systemic disease Flashcards
What is Curth’s postulates?
A well-known set of clinical criteria that were created to help evaluate the temporal relationship between an underlying malignancy and a specific dermatological condition
What is thought about which might like an underlying systemic condition and a dermatological condition?
Concurrent onset Parallel course Uniform site or type of neoplasm Statistical association Genetic linkage
What could blue rubber bleb naevus be related to systemically?
GI haemorrhage
What could erythema nodosum or pyoderma gangrenous be related to systemically?
IBD
What are skin conditions related to diabetes?
Acanthosis nigricans Diabetic bullae Diabetic dermopathy (lots of small papules) Eruptive xanthomas Necrobiosis lipoidica
What are dermal condition that could be related to hyperthyroidism?
Thyroid acropachy
What is thyroid acropachy?
Digital soft-tissue swelling, clubbing of fingers
What skin condition could be related to hypothyroidism?
Pre-tibial myxoedema
How does cutaneous lupus present?
Butterfly rash
Plaques with clear margins
Photosensitivity
Negative antibodies
How do vasculitic rashes occur?
Small vessel vasculitis
How does alopecia happen?
T-lymphocyte, cytokine rejection of hair
How does vitiligo happen?
Destruction of melanocytes - autoimmune
What are the dermal manifestations of carcinoid syndrome?
Episodic flushing
Facial telangiectasia
What affect does ectopic ACTH syndrome have dermatologically?
Hyperpigmentation
What signs can Paget’s disease of the nipple exhibit and what is it usually a sign of?
Eczematous plaque around the nipple/areola
Usually a sign of breast cancer
Where’s does extra-mammary paget’s disease usually occur and how does it present?
Usually axilla or ant-genital areas and looks similar to eczema
How is paraneoplastic pemphigus seen dermatologically and what does it mean systemically?
Erosive stomatitis, rash
Stems from an underlying tumour - non-Hodgkins, Castlemans disease
What is acquired hypertrichosis lanuginosa and what does it mean systemically?
Acute onset of lanugo hairs on face and body
Internal malignancy esp colorectal cancer
What is erythema gyratum repens and what is it associated with systemically?
Concentric erythematous lesions
Associated with lung cancer
What is Bazex syndrome and what is it associated with systemically?
Symmetrical hyperkeratosis of extremities
SCC - bronchial, oropharyngeal etc.
What is Leser-Trelat and what is it associated with systemically?
Eruptive seborrhoeic keratosis
GI adenocarcinomas
What condition can preced malignancy (esp gastric carcinoma) and has a velvety appearance?
Acanthosis nigricans
What are Gottrons papules?
Red maculo-papular lesions over bony prominences
What are the signs of dermatomyositis and what is it associated with systemically?
Inflammatory myopathy and rash: periorbital heliotrope rash, photosensitive, Shawl sign, Gottrons papules
Ovarian/lung/breast cancer
