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Dermatology > Dermatology - skin and systemic disease > Flashcards

Dermatology - skin and systemic disease Flashcards

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Dermatology Board Prep flashcards
1
Q

What is Curth’s postulates?

A

A well-known set of clinical criteria that were created to help evaluate the temporal relationship between an underlying malignancy and a specific dermatological condition

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2
Q

What is thought about which might like an underlying systemic condition and a dermatological condition?

A 
Concurrent onset
Parallel course
Uniform site or type of neoplasm
Statistical association
Genetic linkage
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3
Q

What could blue rubber bleb naevus be related to systemically?

A

GI haemorrhage

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4
Q

What could erythema nodosum or pyoderma gangrenous be related to systemically?

A

IBD

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5
Q

What are skin conditions related to diabetes?

A 
Acanthosis nigricans
Diabetic bullae
Diabetic dermopathy (lots of small papules)
Eruptive xanthomas
Necrobiosis lipoidica
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6
Q

What are dermal condition that could be related to hyperthyroidism?

A

Thyroid acropachy

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7
Q

What is thyroid acropachy?

A

Digital soft-tissue swelling, clubbing of fingers

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8
Q

What skin condition could be related to hypothyroidism?

A

Pre-tibial myxoedema

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9
Q

How does cutaneous lupus present?

A

Butterfly rash
Plaques with clear margins
Photosensitivity
Negative antibodies

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10
Q

How do vasculitic rashes occur?

A

Small vessel vasculitis

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11
Q

How does alopecia happen?

A

T-lymphocyte, cytokine rejection of hair

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12
Q

How does vitiligo happen?

A

Destruction of melanocytes - autoimmune

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13
Q

What are the dermal manifestations of carcinoid syndrome?

A

Episodic flushing

Facial telangiectasia

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14
Q

What affect does ectopic ACTH syndrome have dermatologically?

A

Hyperpigmentation

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15
Q

What signs can Paget’s disease of the nipple exhibit and what is it usually a sign of?

A

Eczematous plaque around the nipple/areola

Usually a sign of breast cancer

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16
Q

Where’s does extra-mammary paget’s disease usually occur and how does it present?

A

Usually axilla or ant-genital areas and looks similar to eczema

17
Q

How is paraneoplastic pemphigus seen dermatologically and what does it mean systemically?

A

Erosive stomatitis, rash

Stems from an underlying tumour - non-Hodgkins, Castlemans disease

18
Q

What is acquired hypertrichosis lanuginosa and what does it mean systemically?

A

Acute onset of lanugo hairs on face and body

Internal malignancy esp colorectal cancer

19
Q

What is erythema gyratum repens and what is it associated with systemically?

A

Concentric erythematous lesions

Associated with lung cancer

20
Q

What is Bazex syndrome and what is it associated with systemically?

A

Symmetrical hyperkeratosis of extremities

SCC - bronchial, oropharyngeal etc.

21
Q

What is Leser-Trelat and what is it associated with systemically?

A

Eruptive seborrhoeic keratosis

GI adenocarcinomas

22
Q

What condition can preced malignancy (esp gastric carcinoma) and has a velvety appearance?

A

Acanthosis nigricans

23
Q

What are Gottrons papules?

A

Red maculo-papular lesions over bony prominences

24
Q

What are the signs of dermatomyositis and what is it associated with systemically?

A

Inflammatory myopathy and rash: periorbital heliotrope rash, photosensitive, Shawl sign, Gottrons papules
Ovarian/lung/breast cancer

25
Q

What is the Shawl sign?

A

The shawl sign is a widespread, flat, reddened area that appears on the upper back, shoulders, and back of the neck. It can worsen with exposure to ultraviolet light.

26
Q

What is Sweet syndrome?

A

A very rare inflammatory skin condition characterized by a sudden onset of fever and painful rash on the arms, legs, trunk, face, or neck.

27
Q

What are bullous pemphigoid, Sweet syndrome, pyoderma gangrenous and acquired ichthyosis all possibly associated with?

A

Malignancy

Dermatology (9 decks)

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