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MRCP Part 2 > Dermatology/Rheumatology > Flashcards

Dermatology/Rheumatology Flashcards

1
Q

Treatment of bowens disease

A

Topical 5 fluoracil

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2
Q

Treatment of rosacea

A

Topical metronidazole (mild symptoms)
Brimonidine gel
Oxytetracycline orally if severe symptoms

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3
Q

What is the most common cardiac manifestation of lupus?

A

Pericarditis

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4
Q

What antibodies are associated with polymyositis?

A

Anti synthetase antibibodies

Anti Jo 1

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5
Q

Causes of osteomalacia

A 
Vitamin D deficiency 
Chronic kidney disease 
Anticonvulsant medications 
Inherited 
Liver cirrhosis
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6
Q

Blood results in osteomalacia

A

Low vitamin D
Low calcium
Low phosphate
Raised alkaline phosphatase

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7
Q

Treatment of osteomalacia

A

Vitamin D supplementation

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8
Q

What is the inheritence pattern of hereditary haemorrhagic telangiesctasia?

A

Autosomal dominant

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9
Q

What are the symptoms of pellagra (niacin deficiency)

A

Dermatitis, diarrhoea and dementia

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10
Q

Treatment of pyoderma gangrenosum?

A

Oral steroids

Ciclosporin/Infliximab in some cases

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11
Q

Blood results in pagets disease?

A

Raised ALP. Normal calcium and phosphate

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12
Q

Treatment for pagets disease

A

Bisphosphonates

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13
Q

What is the most common malignancy associated with acanthosis nigricans

A

Gastrointestinal cancer

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14
Q

What is the gold standard diagnostic investigation for polymyositis?

A

Muscle biopsy

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15
Q

First line treatment for chronic plague psoriasis

A

Topical potent corticosteroid and vitamin D analogue

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16
Q

Antibodies for drug induced lupus?

A

Anti histone antibodies

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17
Q

What are the most common causes of drug induced lupus

A

Procinamide

Hydralazine

18
Q

How does denosumab work?

A

Human monoclonal antibody that prevents the development of osteoclasts by inhibiting RANKL.

19
Q

Antibodies in sjogrens syndrome?

A

Rheumatoid factor
ANA
Anti Ro
Anti LA

20
Q

Which way does the lens dislocate in marfans syndrome?

A

Upward

21
Q

Risk factors for pseudogout

A 
Haemochromatosis 
Hyperparathyroidism 
Low magnesium 
Low phosphate 
Acromegaly 
Wilsons disease
22
Q

Type of crystals in pseudogout

A

Calcium pyrophosphate

Weakly positive birefringent rhomboid shaped crystals

23
Q

What is sezary syndrome?

A 
T cell cutaenous lymphoma 
Symptoms include itching, erythroderma of the palms, soles and face
Atypical T cells
Lymphadenopathy 
Hepatosplenomegaly
24
Q

Antibodies for diffuse cutaneous systemic sclerosis?

A

SCL 70 antibodies

25
Q

Most common cause of death in diffuse cutaneous systemic sclerosis?

A

Interstitial lung disease and pulmonary hypertension

26
Q

Antibodies for limited cutaneous systemic sclerosis?

A

Anti centromere

27
Q

Virus associated with polyarteritis nodosa

A

Hepatitis B

28
Q

What is necrobiosis lipoidica diabeticorum?

A

Shiny, painless areas of yellow/red skin on the shins or people with diabetes

29
Q

What is the triad of symptoms in bechets syndrome?

A

Oral ulcers, genital uclers and anterior uveitis

30
Q

What HLA type is associated with bechets syndrome?

A

HLA B51

31
Q

Antibodies associated with dermatomyositis?

A

Anti Mi 2

32
Q

Is microscopic polyangitis more associated with pANCA or c ANCA?

A

pANCA

33
Q

Antibodies associated with SLE?

A 
ANA 
Rheumatoid factor (20%)
ANti DsDNA (highly specific)
Anti Smith (highly specific)
Anti Ro and Anti La
34
Q

Drugs which worsen psoriasis?

A

Beta blockers, lithium, chlroquine, NSAIDS, ACE inhibitors, infliximab

35
Q

What is pagets disease?

A

A disease of increased bone turnover.

36
Q

Treatment for methotrexate toxicity?

A

Folinic acid

37
Q

What is the criteria for TNF inhibitors in rheumatoid arthritis?

A

Inadequate response to at least two DMARDs including methotrexate

38
Q

What is the most definitive diagnostic test for sjogrens syndrome?

A

Salivary gland biopsy

39
Q

What are the features of stills disease/

A 
Arthralgia 
Elevated ferritin 
Pink maculopapular rash
Pyrexia 
Lymphadenopathy 
RF and ANA negative
40
Q

Treatment for stills disease?

A

NSAIDs
Steroids (may improve symptoms but don’t improve prognosis)
If persisting symptoms methotrexate, IL1 or anti TNF can be considered.

41
Q

Treatment for lichen planus?

A

Potent topical corticosteroids

MRCP Part 2 (11 decks)

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