Dermatology - Pharmacology Flashcards
What is a cream?
mixture of oil and water
What are the two subclassifications of creams their benefits?
Aqueous - water based for water soluble drugs
Oil based - for lipid soluble drugs, moisturising, less greasy than ointments
What forms can topical meds come in?
- Creams
- Oils - oil based, good for dry skin eg eczema
- Gels - water and glycogen based
- Paints/ Tinctures - alcohol based (tinctures anyway), very quick drying, good for putting in skin folds
- Powders
- Pastes - solid
What are some dermatological adverse effects of corticosteroids?
Atrophy of the skin
- epidermal ( tissue paper ) - dermal (striae, purpura, telangiectasia ) - lipoatrophy
Perioral dermatitis and steroid rosacea
Delayed wound healing
Susceptibility to infection
Allergic contact dermatitis
Rebound phenomenon
Tachyphylaxis - tolerance
Hypertrichosis (werewolf syndrome)
Should you start with weaker steroids and work up, or stronger and work down?
stronger and work down
What are the groups of corticosteroids
Group 1 (mild ) Group 2 ( moderately potent ) stronger Group 3 ( potent ) Group 4 ( very potent)
How does tar work as a derm med?
suppress DNA synthesis
reduce epidermal proliferation
anti pruritic
potentiated by ultraviolet light
What are some indications for tar?
Chronic eczema
Stable plaque psoriasis
Pustular psoriasis of hands and feet
How does salycyclic acid “work”?
“dissolves intracellular cement”
What class of medication is salycylic acid?
a keratolytic
What are some indications for keratolytics?
- Hyperkeratotic eczema/ psoriasis
- Warts
- Nail remover
- Cosmetic
What are subcategories of moisturisers?
- Emollients - replace the natural oil, go into the cells
- Occlusive - stop water from leaving
- Humectants - bind water
