Dermatology

Question 1

what medication inhibits the fungal enzyme squalene epoxidase

Answer 1

Terbinafine

Question 2

Langerhans cell histiocytosis

Answer 2

clinical manifestation of recurrent otitis media, skin rash and the lytic bone lesions. Langerhans cell histiocytosis is a multi-system disease and it is a proliferative condition of the dendritic cells in the skin. The disease involves the formation of multiple granulomas throughout the body. It commonly presents in childhood but can also be found in adults A classic electron microscopic finding of a biopsy which helps identify the condition is the presence of Birbeck granules which are tennis-racket shaped.

eatures
bone pain, typically in the skull or proximal femur
cutaneous nodules
pituitary involvement: leads to diabetes insipidus due to pituitary stalk involvement
pulmonary involvement: More common in adults, presenting with dyspnoea, cough, and chest pain
recurrent otitis media/mastoiditis
tennis racket-shaped Birbeck granules on electromicroscopy

Question 3

Pemphigus vulagris - Ab against what?

Answer 3

Antibodies against desmoglein 3 are seen in pemphigus vulgaris