Dermatological emergencies

Question 1

4 types of reactions

Answer 1

type 1 anaphylaxis
type 2 cytotoxic
type 3 immune medicated
type 4 cell medicated

Question 2

what is the most common type of drug hypersensitivity reaction

Answer 2

morbilliform

Question 3

presentation of morbilliform

Answer 3

5- 10 day onset
systemic- fever, unwell
skin-maculopapular rash

Question 4

what serious conation can morbilliform progress too

Answer 4

TEN/SJS

Question 5

what drugs can cause morbilliform reactions

Answer 5

penicllin, erythromycin, NSAID

Question 6

treatmetn for morbilliform reactions

Answer 6

antihistamine, emollient, topical steroid.

Question 7

what does AGEP stand for

Answer 7

acute generalised exanthematous pustulosis

Question 8

presentation fo AGEP

Answer 8

2 day onset
starts in face + flexors
erythema + widespread pustules.

Question 9

main causes of AGEP

Answer 9

tetracyclines, antifungals, calcium blockers.

Question 10

define DRESS

Answer 10

drug hypersensitiyiy syndrome

Question 11

presentation of DRESS

Answer 11

2-8 weeks after interaction
maculoppapular rash, pustules, erythroderma
mutliple organ inlovmemtn

Question 12

diagnostic crietris for DRESS

Answer 12

fver > 38, lymphadenopathy, atleast 1 organ involvment

Question 13

define erythreoderma

Answer 13

inflammation of all of the skin ( > 90%)

Question 14

presentation of erythroderma

Answer 14

puritis
hair loss
exfoliation
hyperkeratosis of palms/ soles.
lymphadenopathy

Question 15

common causes of erythroderma

Answer 15

drugs
dermatitis-eczema + contact
psorias
immunobullous disorders
cutaneous T cell lymphoma
HIV

Question 16

complication erythroderma

Answer 16

infection
loss of thermoregulation
cardiac failure
fluid/ electrolyte imbalance

Question 17

management of erythroderma

Answer 17

skin swabs
bloods- FBC, U+ E’s, CRP, LFT
BLAND EMOLLIENT

Question 18

3 conditions of mild to severe skin interactions

Answer 18

erythema mulitofrme
SJS
TEN