Dermatisis/eczema Flashcards
WHAT TEAM??!
WILDCATS!!
define the following terms: hyperkeratosis parakeratosis acanthosis papillomatosis Spongiosis
- increased thickness of the keratin layer
- persistence of nuclei in the keratin layer
- increased epidermal thickness
- irregular epithelial thickening
- oedema between keratinocytes due to inflammation
describe:
acute phase eczema (4)
chronic phase eczema (3)
-papulovesicular
erythematous
spongiosis
oozing/scaling/crusting
-lichinification
elevated plaque
increased scaling
Name the 7 different types of dermatitis
- pathogenesis
- histology
contact allergic
-type 4, spongiotic dermatitis
contact irritant
-trauma e.g. soap/water, spongiotic dermatitis
atopic
-genetic + environmental= inflammation, spongiotic dermatitis
Drug related
-type 1/4, spongiotic dermatitis + eosonophils
photo induced
-UV light reaction, spongiotic dermatitis
lichen simplex
-physical trauma- scratching, spongiotic + external trauma
stasis dermatitis
-physical trauma and hydrostatic pressure, spongiotic + extraversion of RBCs
Contact allergic dermatitis
- describe the pathophysiology
- investigations
-antigen processed by langerhans cells in the epidermis
antigen then presented to Th cells in the dermis
sensitised Th cells then migrate to lymphatics
then to regional nodes where antigen presentation amplified
upon challenge by subsequent antigen sensitised T cells proliferate and infiltrate the skin
-patch testing
Atopic eczema
- general features (5)
- chronic changes (3)
- diagnostic criteria (5)
- treatment (7)
-pruritus ill defined erythema & scaling generalised dry skin Flexural distribution Atopic disease hx
-lichenification excoration (break in the skin) secondary infection (crusting= staph aureus)
-pruritus + visible flexure rash
hx of atopy
hx flexure rash
general dry skin
-emollients Avoid irritants topical steroids treat infection phototherapy- UVB systemic immunosuppresents biologic agents
