Derm drugs

Question 1

Isotretinoin

• MOA
• indications
• SE
• contra

Answer 1

MOA

• affects all 4 of the pathophys mechanisms of acne (most effective medication for acne vulgaris)
  1. follicular hyerkeratinization
  2. increased sebum production
  3. Propionibacterium acne overgrowth
  4. inflammatory response

INDS
*severe or refractory acene/cystic

SE

1. dry skin and lips—-MC
2. dry eyes
3. increased triglycerides and cholesterol
4. arthalgias, myalgias,
5. hepatits
6. leukopenia
7. premature long bone closure
8. photosensitivity
9. worsening of DM
10. HA
11. idiopathic intracranial HTN

Contra
***highly teratogenic–>get TWO preg tests b4 tx AND monthly while on tx–also PT needs two forms of BC during tx

*****due to teratogenic SE–>neeed to sign up for ipledge

Question 2

Topical minoxidil

moa
se

Answer 2

MOA
*widens BVs—>more blood, oxygen and nutrients to area–>promotes growth phase of hair

SE
*puriritis and local irritation with flaking

Question 3

PO Fineasteride
-drug class
-moa
se

Answer 3

5-alpha reductase type 2 inhibitor
*androgen inhibitor

MOA: inhibs conversion of testosterone to dihydrotestosterone

SE

• decr libido
• sexual or ejaculatory dysfunction
• incr risk of high-grade prostate CA
• category X

Question 4

contraindications for systemic antifungals

Answer 4

ETOH

hepatitis