Derm Flashcards
1
Q
- What are papules ?
A
- Small, red, inflamed bumps
2
Q
- What are pustules
A
- Papules (small, red inflamed bumps) with pus in them
3
Q
- How would you describe an acne rash ?
A
- Papules and pustules
- Comedones
- Excessive inflammation may result in icepick and hypertrophic scars
4
Q
- How is mild to moderate acne managed ?
A
- Fixed combination of topical adapalene with topical benzoyl peroxide
5
Q
- How is moderate to severe acne managed ?
A
- Fixed combination of adapalene with benzoyl peroxide with oral lymecycline or doxycycline
- COCP can be used instead of oral Abx in women
- Oral isotretinoin can be used only under specialist supervision
6
Q
- What is acne fulminans ?
A
- Very severe acne associated with systemic upset
- Hospital admission is required and condition usually responds to steroids
7
Q
- How do arterial ulcers typically present ?
A
- Occur on toe or heel
- Typically ‘deep punched out’ appearance
- Painful
- Cold with no palpable pulse
- Low ABPI measurement
8
Q
- How are arterial ulcers managed ?
A
- Urgent referral
9
Q
- What differentiates arterial ulcers ?
A
- Arterial = toe or foot
- Smaller and deeper
- Well defined borders
- Punched out appearance
- Pale and cold due to blood supply
- Painful and less likely to bleed
- Pain worse at night on elevation
10
Q
- What differentiates venous ulcers ?
A
- Gaiter area (top of foot and bottom of calf muscle)
- Chronic venous changes such as hyperpigmentation and venous eczema
- Larger, more superficial and irregular
- More likely to bleed
- Less painful
- Relieved on elevation
11
Q
- How are venous ulcers managed ?
A
- Vascular surgery where mixed or arterial ulcers are suspected
- Tissue viability / specialist leg ulcer clinics in complex or non-healing ulcers
- Dermatology where an alternative diagnosis is suspected, such as skin cancer
- Pain clinics if the pain is difficult to manage
- Diabetic ulcer services (for patients with diabetic ulcers)
12
Q
- What is involved in good wound care ?
A
- Cleaning the wound
- Debridement (removing dead tissue)
- Dressing the wound
- Compression therapy is used to treat venous ulcers (after arterial disease is excluded with an ABPI).
- Pentoxifylline (taken orally) can improve healing in venous ulcers (but is not licensed).
- Antibiotics are used to treat infection.
- Analgesia is used to manage pain (avoid NSAIDs as they can worsen the condition).
13
Q
- How would you describe eczema ?
A
- Pruritus
- Erythema
- Skin lesions
- Acute lesions: Characterised by erythematous papules or vesicles that may coalesce into larger plaques with serous exudate
14
Q
- How are eczema flares managed ?
A
- Thicker emollients
- Topical steroids
- Wet wraps
15
Q
- How does eczema herpeticum present ?
A
- Commonly seen in children with atopic eczema and often presenting as a rapidly progressing painful rash
- Monomorphic punched-out erosions (circular, depressed, ulcerated lesions) usually 1-3 mm in diameter are typically seen
16
Q
- How is eczema herpeticum managed ?
A
- This is a potentially life-threatening and children should be admitted for IV aciclovir
17
Q
- Describe basal cell carcinomas
A
- ‘rodent’ ulcers
- Slow growth and local invasion
- Many types – most common is nodular BCC
- Sun-exposed sites – especially the head and neck account for the majority of lesions
- Initially a pearly, flesh-colored papule with telangiectasia
- May later ulcerate leaving a central ‘crater’
18
Q
- Where do basal cell carcinomas typically develop ?
A
- Sun exposed sights – especially the head and neck account for the majority of lesions
19
Q
- How are basal cell carcinomas managed ?
A
- Routine referral
- Surgical removal
- Curettage
- Cryotherapy
- Topical cream: imiquimod, fluorouracil
- Radiotherapy
20
Q
- How do superficial epidermal burns present ?
A
- Red and painful
- No blisters
21
Q
- How do partial thickness (superficial dermal) burns present ?
A
- Pale pink
- Painful
- Blisters
- Slow cap refill
22
Q
How do partial thickness (deep dermal) burns present ?
A
- Typically white but may have patches of non-blanching erythema
- Reduced sensation, painful to deep pressure
23
Q
- How do full thickness burns present ?
A
- White (waxy)/brown (leathery)/ black in colour
- No blisters
- No pain
24
Q
- When to refer a burn to secondary care ?
A
- All deep dermal and full-thickness burns.
- Superficial dermal burns of more than 3% TBSA in adults, or more than 2% TBSA in children
- Superficial dermal burns involving the face, hands, feet, perineum, genitalia, or any flexure, or circumferential burns of the limbs, torso, or neck
- Any inhalation injury
- Any electrical or chemical burn injury
- Suspicion of non-accidental injury
25
Q
- What is the MCC of cellulitis ?
A
- Streptococcus pyogenes
- Less common staph aureus
26
Q
- Cellulitis presentation
A
- Erythema Well defined margins but some cases may present with diffuse erythema
- Blisters and bullae may be seen with more severe disease
- Swelling
- Systemic upset – Fever, Malaise and Nausea
27
Q
- What are the 2 types of contact dermatitis ?
A
- Irritant contact dermatitis – due to weak acids or alkalis. Often seen on hands – erythema, crusting and vesicles are rare
- Allergic contact dermatitis – type IV hypersensitivity reaction – hair dyes – acute weeping eczema which responds to topical potent steroid treatment
28
Q
- RFs for malignant melanoma
A
- History of skin cancer, melanoma, or atypical naevi
- Family history of melanoma
- Pale skin (Fitzpatrick skin type I and II)
- Red or light-coloured hair
- High freckle density
- Light coloured eyes
- History of sunburn
- Sun exposure or tanning bed exposure
- Large amounts of moles
- Increasing age
- Immunosuppression
- Outdoor occupation
- Genetic syndromes with skin cancer predisposition (for example, xeroderma pigmentosum)
29
Q
- Types of malignant melanoma
A
- Superficial spreading
- Nodular
- Lentigo Maligna
- Acral lentiginous
30
Q
How does Superficial spreading malignant melanoma present ?
A
- 70% of cases
- Arms, legs, back and chest
- Common in young
- Appearance: a growing mole(s)
31
Q
- How does Nodular malignant melanoma present ?
A
- 2nd most common
- Typically affects: sun exposed skin, middle-age people
- Appearance: red or black lump which bleeds or oozes
32
Q
- How does Lentigo Maligna malignant melanoma present ?
A
- Less common
- Typically affects: chronically sun-exposed skin and older people
- Appearance: a growing mole
33
Q
- How does Acral lentiginous malignant melanoma present ?
A
- Rare
- Nails, palms or soles
- Common in people with darker skin pigmentation
- Subungual pigmentation (Hutchinson’s sign or on palms or feet)
34
Q
- What is the ABCDE criteria of assessing skin lesions ?
A
- A – asymmetrical shape
- B – border irregularity, including poorly defined margins
- C – colour change and variation
- D – diameter of the mole (most melanomas are >6mm)
- E – evolving (such as changing in size, shape and colour)
35
Q
- Management of malignant melanoma ?
A
- Suspicious lesions should undergo excision biopsy
- Once diagnosis is confirmed the pathology report should be reviewed to determine whether further re-excision of margins is required
36
Q
- Key DDs for malignant melanoma ?
A
- Benign naevus
- Lentigines
- Seborrhoeic keratoses
- Dermatofibroma
- Pigmented BCC
37
Q
- How do malignant melanoma typically present ?
A
- Asymmetrical
- Irregular borders
- 2 or more colors – pink/grey/white in a brown lesion increased chance of malignancy
- Malignancy is more likely to be in lesions over 6mm in diameter
- Evolution – quick growth and rapid appearance change are concerning
38
Q
- How does seborrheic keratoses present ?
A
- Benign epidermal skin lesions seen in older people
- Large variation in colour from flesh to light-brown to black
- Stuck on appearance
- Keratotic plugs may be seen on the surface
39
Q
- Management of seborrheic keratoses ?
A
- Reassurance about benign nature of the lesion is an options
40
Q
- What are RFs for pressure ulcers ?
A
- Malnourishment
- Incontinence: urinary and faecal
- Lack of mobility
- Pain
41
Q
- How are pressure ulcers classified ?
A
- Waterlow score
42
Q
- How does psoriasis present ?
A
- Raised red, scaly patches on the skin
43
Q
- What are subtypes of psoriasis ?
A
- Plaque psoriasis
- Flexural psoriasis
- Guttate psoriasis
- Pustular psoriasis
44
Q
- How does plaque psoriasis present ?
A
- The most common sub-type resulting in the typical well-demarcated red, scaly patches affecting the extensor surfaces, sacrum and scalp
45
Q
- How does guttate psoriasis present ?
A
- Transient psoriatic rash frequently triggered by a streptococcal infection. Multiple red, teardrop lesions appear on the body
46
Q
- How does pustular psoriasis present ?
A
- Commonly occurs on the palms and soles
47
Q
- How does flexural psoriasis present ?
A
- In contrast to plaque psoriasis the skin is smooth
48
Q
- What can exacerbate psoriasis ?
A
- Trauma
- Alcohol
- Drugs e.g. BB, lithium NSAIDs, ACE-I etc
- Withdrawal of systemic steroids
- Streptococcal infection may trigger guttate psoriasis.
49
Q
- GP management of plaque psoriasis
A
- Regular emollients may help to reduce scale loss and reduce pruritus
- 1st line: NICE recommend: a potent corticosteroid applied once daily plus vitamin D analogue applied once daily for up to 4 weeks
- 2nd line: if no improvement after 8 weeks then offer: a vitamin D analogue twice daily
- 3rd-line: if no improvement after 8-12 weeks then offer either: a potent corticosteroid applied twice daily for up to 4 weeks, or a coal tar preparation applied once or twice daily
- Short-acting dithranol can also be used
- Secondary care
50
Q
- Secondary care management of plaque psoriasis
A
- Phototherapy - Adverse effects: skin ageing, squamous cell cancer (not melanoma)
- Systemic therapy:
- Oral methotrexate is used first-line. It is particularly useful if there is associated joint disease
- Ciclosporin
- Systemic retinoids
- Biological agents: infliximab
51
Q
- What are features of Squamous cell carcinoma ?
A
- The most common variant of skin cancer
- Typically on sun-exposed sites such as the head, neck or dorsum of the hands and arms
- Rapidly expanding, painless ulcerate nodules
- May have a cauliflower-like appearance
- May be areas of bleeding
52
Q
- Risk factors for squamous cell carcinoma ?
A
- Excessive exposure to sunlight/psoralen UVA therapy
- Actinic keratoses and Bowen’s disease
- Immunosuppression e.g. following renal transplant, HIV
- Smoking
- Long-standing leg ulcers (Marjolin’s ulcer)
- Genetic conditions e.g. xerpderma pigmentosum
53
Q
- Management of squamous cell carcinoma
A
- Surgical excision within 4mm margins if lesion < 20 mm in diameter
- If tumour > 20mm then margins should be 6 mm
54
Q
- Good prognosis for a squamous cell carcinoma ?
A
- Well differentiated tumours
- < 20mm in diameter
- < 2mm deep
- No associated disease
55
Q
- Poor prognostic indicators for a squamous cell carcinoma ?
A
- Poorly differentiated tumour
- > 20 mm in diameter
- > 4mm deep
- Immunosuppression for whatever reason
56
Q
- What is urticaria ?
A
- Local or generalised superficial swelling of the skin
- The MCC is allergy although non-allergic causes are seen
57
Q
- How does urticaria present ?
A
- Pale, pink raised skin
- Described as ‘hives’ ‘wheals’ ‘nettle rash’
- Pruritic
58
Q
- How is urticaria managed ?
A
- Non-sedating antihistamines e.g. loratadine or cetirizine 1st line
- These should be continued for up to 6 weeks
- Sedating anti-histamine e.g. chlorphenamine may be used in addition and for troublesome sleep symptoms
- Prednisolone is used for severe or resistant episodes
59
Q
- What is a dermatofibroma ?
A
- DD of malignant myeloma
- Common benign fibrous skin lesions
- Caused by abnormal growth of dermal dendritic histocyte cells, often following a precipitating injury
60
Q
- What are common features of a dermatofibroma ?
A
- Solitary firm papule or nodule, typically on a limb
- Typically around 5-10mm in size
- Overlying skin dimples on pinching the lesion
61
Q
- What is Erythema Nodsoum ?
A
- Inflammation of the subcutaneous fat
- Typically causing tender, erythematous, nodular lesions
- Usually occurs over shins but may occur elsewhere e.g. forearms or thighs
- Usually resolves within 6 weeks lesions healing without scarring
62
Q
- What can cause erythema Nodsoum ?
A
- Infection
- Streptococci
- Tuberculosis
- Brucellosis
- Systemic disease
- Sarcoidosis
- Inflammatory bowel disease
- Behcet’s
- Malignancy/lymphoma
- Drugs
- Penicillins
- Sulphonamides
- combined oral contraceptive pill
- Pregnancy