Depression & meds Flashcards
What is the typical depressive disorder that is characterized by a depressed mood w/ or w/o psychosis, has no history of manic behavior & individual loses interest or pleasure in usual activities?
Major Depressive Disorder (MDD)
What neurotransmitters are involved in Depression?
Norepinephrine, Serotonin & Dopamine
What is the term used to describe an increase of a cellular component or (more receptors)?
Up-Regulation
What is important for executive functions of memory, reasoning, problem solving & planning?
Norepinephrine
How many weeks might it take for an antidepressant med to take effect?
6 weeks
What disorder is consistently chronically depressed w/ no bad days then good days impairs social & occupational function & cannot be attributed to substance use of another medical condition?
Major Depressive Disorder
What is the term used to describe going back to a normal amount of receptors?
Down-regulation
What neurotransmitter is involved in mood, appetite, libido & cognition?
Serotonin (SSRI’s)
What action do SSRI’s have in the brain?
Block reuptake of serotonin
Why might it take up to 6 weeks for an antidepressant to take effect?
bc of down-regulation, it needs to get back to physiological normalcy
How many weeks must symptoms be present in a pt. diagnosed w/ MDD?
At least 2 weeks
What disorder is referred to as sad or “down in the dumps”, is a more milder form of MDD bc individual is function-able & will still have thing to make them laugh, but has no evidence of psychotic symptoms?
Dysthymic Disorder
What is the mechanism by which antidepressant meds achieve their desired effect?
increase levels of serotonin & norepinephrine
What must the nurse be on alert for w/ a pt receiving antidepressants?
Negative symptoms-thoughts of suicide
How long is a pt w/ Dysthymic Disorder chronically depressed for?
most of the day, more days than not for at least 2 years
What disorder is considered more than PMSing, have a depressed mood, excessive anxiety, mood swings, & a decrease in interests in activities?
Premenstrual Dysphoric Disorder
What is the most potentially life-threatening adverse effect of MAOI’s?
Hypertensive crisis
What classification of a med is Evexor?
SNRI
How long do symptoms of premenstrual dysphoric disorder last for?
2 weeks of cycle
What classification is the medication marplan parnate?
MAOI
What classification is the medication welbutrin?
NDRI
When do symptoms of premenstrual dysphoric disorder begin, start to improve, & become minimal or absent?
begin- week prior to menses, improve- w/in few days after onset of menses, minimal/absent- week post-menses
What disorder is associated w/ intoxication/withdrawal of substances like beta blockers, opioids, or benzodiazepines & can cause significant distress/impairment in social/occupational or other areas of functioning?
Substance-induced Depressive Disorder
What disorder is a direct physiological effect of a general medical condition?
Depressive Disorder associated w/ another medical condition
Is depression life long?
NO!
What disorder may be caused by a deficiency in norepinephrine, serotonin & dopamine & excessive cholinergic transmission?
Depression
What classification are the medications Prozac & Zoloft?
SSRI’s
What classification are the meds Imipramine, Clomipramine & doxepin?
Tricyclic
What disorder may be caused by a possible failure w/in hypothalamic-pituitary-adrenocortical axis such as thyroid problems & pituitary problems from stress?
Depression-neuroendocrine disturbances
What is the triad of negative distortions in depression?
Negative expectations of the environment, self, & future
What is the predisposing factors that includes: med side effects, neurological disorders (CVA, brain tumors-temporal lobes), electrolyte disturbances, hormonal disturbances (thyroid, adrenal cortex, estrogen, progestogen), & nutritional deficiencies?
Physiological influences of depression
In the cognitive theory Beck views primary disturbances in depression as ______ rather than ______. & that depression is the product of negative thinking.
cognitive; affective
Stress can equal a?
cholinergic attack
What is the black box warning on antidepressants?
increase risk for suicide