Depression, Bipolar Flashcards

1
Q

Some facts about depression?

A

Universal experience. 5-25% of the population. May be masked by alcohol or substance abuse. Acting out in children and teens. Incidence is higher in women.

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2
Q

People with what are at a higher risk for depression?

A

Co-occuring chronic medical problems. Eg hypertension, backache, diabetes, heart problems, arthritis.
Depression is often secondary to a medical condition

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3
Q

What are some examples of symptoms of depression?

A
  1. Depressed mood or irritable most of the day, nearly every day
  2. Decreased interest or pleasure in most activities, most of each day
  3. Significant weight change (5%) or change in appetite
  4. Change in sleep: Insomnia or hypersomnia
  5. Change in activity: Psychomotor agitation or retardation
  6. Fatigue or loss of energy
  7. Guilt/worthlessness: Feelings of worthlessness or excessive or inappropriate guilt
  8. Concentration: diminished ability to think or concentrate, or more indecisiveness
  9. Suicidality: Thoughts of death or suicide, or has suicide plan
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4
Q

Assessment guidelines for depression?

A

Risk of self harm to harm to others? Medical issues? History of depression? Support systems? Precipitating events? Psychosocial assessment?

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5
Q

Health teaching for depression?

A

No fault diagnosis. Their target symptoms and symptoms of suicide risk (e.g. medications). Follow-up therapy. Healthy living skills. Community resources.

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6
Q

What does follow-up therapy as far as depression goes include?

A

Clarify stressors and measures to reduce impact of stressor through problem solving. aftercare facilities, relapse prevention

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7
Q

Explain ECT for depression?

A

Electroconvulsive therapy
NPO 8 hours prior. General anesthetic. Muscle paralyzing agent. Oxygen. After care, including reassessing, reorienting, and short term memory loss.

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8
Q

Other types of medical management for depression?

A

Stimulation therapies, photo therapy, vagus nerve stimulation, rapid transcranial magnetic stimulation, deep brain stimulation, medications

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9
Q

What do all antidepressant medications have in common?

A

All have discontinuation syndrome, gradually wean off of them. About hazardous activities due to the sedation effect. “Wash out” period between trying different antidepressants. Adverse effects. “Start low, go slow”

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10
Q

What are examples of three s/s that one must have to have serotonin syndrome, after having been taking a drug that changes the body’s serotonin level?

A

Mental status changes, diarrhea or ab pain, heaving sweating, fever, altered muscle tone, overactive reflexes, shivering, tremors, uncoordinated movements (ataxia)

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11
Q

Treatment of serotonin syndrome?

A

Control hyperthermia, stop serotenergic drugs, treat muscle rigidity and agitation with clonazepam, benzotropine, lorazepam. Anticonvulsants for seizures, cyproheptadine

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12
Q

Explain alcohol and antidepressants>

A

Adds to the CNS depression of antidepressant meds, impairment occurs after fewer drinks than in person not taking these meds, may render antidepressant ineffective

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13
Q

What do tricyclics do?

A

Block reuptake of NE and 5-HT, thus increasing availability in the synapse. Side effects include anticholinergic, histamine blockade, and cardiovascular.

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14
Q

Tricyclic contraindications and effect onset?

A

Narrow angle glaucoma and history of seizures are contraindicated. Narrow therapeutic window
Lethal in OD. 10-14 days for initial effect and 4-8 weeks for full effect.

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15
Q

What do SSRIs do?

A

Selectively blocks the reuptake of 5-HT in synapse, thus increasing available serotonin with less side effects. First-line therapy for depression.

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16
Q

Side effects of SSRIs?

Adverse effects?

A

Fatigue, nausea, diarrhea, dry mouth, dizziness, tremor, sexual dysfunction, lack of libido
Risk for cerebral microbleeds, strokes.

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17
Q

What do MAOIs do?

A

Block an enzyme needed to metabolism norepinephrine, 5-HT, and D, thus increasing the neurotransmitters in the synapse.

18
Q

Side and adverse effects of MAOIs?

A

Orthostatic hypotension, weight gain, anticholinergic, sexual dysfunction, insomnia.

19
Q

What can happen when one takes MAOIs and eats tyramine? How? What else should be avoided?

A

Hypertensive crises. Caused by the MAOIs decreasing the amount of monoamine oxidase used to break down tyramine and tryptophan in the liver.
Avoid OTC meds.

20
Q

First signs of a hypertensive crises?

A

Severe headache, followed by neck stiffness, N/V, sweating, tachycardia. Death can result from circulatory collapse or intracranial bleeding.

21
Q

What foods contain tyramine?

A

Aged cheeses, pickled or smoked fish, yeast breads, lunchmeat, soy products.
Draft beer, wine, and yogurt in moderation.

22
Q

What does one look for when evaluating the effectiveness of anti-depressant meds

A

Appetite/weight. Ability to get self up, attend and participate in groups and complete tasks. Sleep quality and amount. Suicide assessment.

23
Q

Bipolar with mania diagnosis requires three or more of the following?

A

Inflated self-esteem, grandiosity, hyperverbal and pressured speech, flight of ideas, racing thoughts, distractibility, decreased need for sleep, increased goal activity, psychomotor agitation, excessive involvement in pleasurable activities that have a high potential for painful consequences.

24
Q

What is mania, especially as relates to bipolar disorder?

A

Abnormally and persistently elevated, expansive, or irritable mood lasting at least 1wk.

25
Q

What is the difference between bipolar 1 and bipolar 2?

A

1 requires that pt had a full blown mania either currently or in the clients history.
2 is the client has had a hypomania but no full-blown mania.

26
Q

What should be included in a nursing assessment for bipolar disorder?

A

Physiological safety, hydration, cardiac status, sleep exhaustion, danger to self/others, inappropriate sexual activity, uncontrolled spending/giving. Knowledge of disorder, meds, support groups, and organizations.

27
Q

What is involved in the different phases of mania?

A

Acute: medical stabilization, maintaining safety, self-care needs.
Continuation: maintaining med adherence, psychoeducational teaching, referrals, learning about signs of relapse.
Maintenance: preventing relapse, support groups, med adherence, psychotherapy

28
Q

The ability to contain or diminish unacceptable or inappropriate heavier in a positive, professional manner.

A

Limit-setting. An interpersonal skill that maintains the self-esteem of all parties and establishes personal boundaries.

29
Q

What skills are used in limit setting? What is avoided?

A

Assertive communication techniques, detached concern, consistency with behavioral expectations and consequences.
Avoid setting limits out of proportion to the situation and colluding with the patient splitting up the staff.

30
Q

Interventions for a structures and safe milieu?

A

Decrease environmental stimuli by limiting joking and noise. Avoid competition, provide structured solitary activities with the staff. Protect the patient from the consequences of poor judgement.

31
Q

Priorities and interventions during acute mania?

A

Structure in a safe milieu, nutrition, sleep, hygiene, elimination

32
Q

Mechanism for lithium carbonate mood stabilizer?

A

First-line agent for bipolar disorder. Alters sodium transport in nerve and muscle cells, and inhibits the release of norepinephrine and dopamine.

33
Q

Therapeutic windows for lithium?

A
Very narrow therapeutic window.
Therapeutic: 0.8-1.4 mEq/L
Maintenance: 0.4-1.3 mEq/L
Toxic: 1.5-2.0 mEq/L
Higher doses during acute mania, lower maintenance dose
34
Q

Contraindications for lithium?

A

Renal, thyroid, or neurological disorders. Cardiovascular disease. Pregnancy and breast feeding.

35
Q

Long term risks for lithium?

A

Hypothyroidism. Impairment of the kidney’s ability to concentrate urine, AKA nephrogenic diabetes insidious.

36
Q

Lithium drug interactions?

A

Any drug that affects sodium levels. Diuretics, low-salt diet, NSAIDs, halloo, aminophylline

37
Q

What should be taught to be a patient who is taking lithium?

A

Adequate fluid intake. Awareness of heavy sweating and the need to replace fluids and electrolytes. Don’t change salt intake. Take with food or milk. Symptoms of toxicity.

38
Q

Why are anxiolytics used with mania?

A

Treatment-resistant mania and psychomotor agitation.
clonazepam
lorazepam

39
Q

Why are atypical antipsychotics used with mania?

A
Sedative properties. 
olanzapine
risperidone
aripiprazole
ziprasidone
quetiapine
40
Q

How long do mood stabilizers take to work?

A

Mania is 1-3 weeks

Depression is 4-6 weeks