Depression, Bipolar Flashcards
Some facts about depression?
Universal experience. 5-25% of the population. May be masked by alcohol or substance abuse. Acting out in children and teens. Incidence is higher in women.
People with what are at a higher risk for depression?
Co-occuring chronic medical problems. Eg hypertension, backache, diabetes, heart problems, arthritis.
Depression is often secondary to a medical condition
What are some examples of symptoms of depression?
- Depressed mood or irritable most of the day, nearly every day
- Decreased interest or pleasure in most activities, most of each day
- Significant weight change (5%) or change in appetite
- Change in sleep: Insomnia or hypersomnia
- Change in activity: Psychomotor agitation or retardation
- Fatigue or loss of energy
- Guilt/worthlessness: Feelings of worthlessness or excessive or inappropriate guilt
- Concentration: diminished ability to think or concentrate, or more indecisiveness
- Suicidality: Thoughts of death or suicide, or has suicide plan
Assessment guidelines for depression?
Risk of self harm to harm to others? Medical issues? History of depression? Support systems? Precipitating events? Psychosocial assessment?
Health teaching for depression?
No fault diagnosis. Their target symptoms and symptoms of suicide risk (e.g. medications). Follow-up therapy. Healthy living skills. Community resources.
What does follow-up therapy as far as depression goes include?
Clarify stressors and measures to reduce impact of stressor through problem solving. aftercare facilities, relapse prevention
Explain ECT for depression?
Electroconvulsive therapy
NPO 8 hours prior. General anesthetic. Muscle paralyzing agent. Oxygen. After care, including reassessing, reorienting, and short term memory loss.
Other types of medical management for depression?
Stimulation therapies, photo therapy, vagus nerve stimulation, rapid transcranial magnetic stimulation, deep brain stimulation, medications
What do all antidepressant medications have in common?
All have discontinuation syndrome, gradually wean off of them. About hazardous activities due to the sedation effect. “Wash out” period between trying different antidepressants. Adverse effects. “Start low, go slow”
What are examples of three s/s that one must have to have serotonin syndrome, after having been taking a drug that changes the body’s serotonin level?
Mental status changes, diarrhea or ab pain, heaving sweating, fever, altered muscle tone, overactive reflexes, shivering, tremors, uncoordinated movements (ataxia)
Treatment of serotonin syndrome?
Control hyperthermia, stop serotenergic drugs, treat muscle rigidity and agitation with clonazepam, benzotropine, lorazepam. Anticonvulsants for seizures, cyproheptadine
Explain alcohol and antidepressants>
Adds to the CNS depression of antidepressant meds, impairment occurs after fewer drinks than in person not taking these meds, may render antidepressant ineffective
What do tricyclics do?
Block reuptake of NE and 5-HT, thus increasing availability in the synapse. Side effects include anticholinergic, histamine blockade, and cardiovascular.
Tricyclic contraindications and effect onset?
Narrow angle glaucoma and history of seizures are contraindicated. Narrow therapeutic window
Lethal in OD. 10-14 days for initial effect and 4-8 weeks for full effect.
What do SSRIs do?
Selectively blocks the reuptake of 5-HT in synapse, thus increasing available serotonin with less side effects. First-line therapy for depression.
Side effects of SSRIs?
Adverse effects?
Fatigue, nausea, diarrhea, dry mouth, dizziness, tremor, sexual dysfunction, lack of libido
Risk for cerebral microbleeds, strokes.