Depression/Bipolar Flashcards
SSRI-induced activation is most common from which 2 SSRI’s?
Prozac
Zoloft
On average how long do pediatric depressive episodes last?
7 months
What % of children with an initial depressive episode will have their depression resolve spontaeously?
40%
What are the 2 FDA approved meds for MDD?
- Prozac (8+ y/o)
- Lexapro (12+ y/o)
What % of individuals diagnosed with Bipolar disorder had symptoms between the age of 13-18 and before 13y/o?
13-18: 40%
Before 13y/o: 25%
What percentage of patients with Bipolar disorder had symptoms beginning at age 13 or earlier?
25-30%
What is the primary finding of the Treatment of Adolescent Depression Study (TADS)?
Fluoxetine + CBT resulted (combo) in greater rate of remission of depressive symptoms
The Treatment of SSRI-resistant Depression in Adolescents (TORDIA) trial looked at adolescents who had not responded to a previous 2 month course of an SSRI. Meds used were: Paroxetine, Citalopram, Fluoxetine, Venlafaxine. Patients who switched to another SSRI and added CBT had a response rate of ______?
Which of the meds was associated with increased side effects?
55% response rate, no difference in which med was switched to
Venlafaxine associated with increased SE
What 8 meds are FDA approved for pediatric Bipolar disorder?
- Lithium (mania/mixed/maintenance, >7y/o)
- Abilify (mania/mixed/maintenance, >10y/o)
- Asenapine (mania, >10y/o)
- Olanzapine + fluoxetine combo (bipolar one depression, >10y/o)
- Risperidone (mania, >10y/o)
- Seroquel XR (mania, >10y/o)
- Olanzapine (mania, >13y/o)
- Lurasidone (bipolar depression, >10y/o)
- Lamictal (maintenance/depression) ?
AALLOORS*
What commonly precedes an adolescent suicide attempt?
confessing suicidal thoughts to a friend
How often does the FDA recommend following up with a youth started on an AD?
every week for the first month, then every other week thereafter
The prevalence of MDD is approximately _____% in children and ______% in adolescents.
2% in children
4-8% in adolescents
DECREASED OR INCREASED
Sleep disturbances have been implicated in depression. This includes ____ REM latency, _____ REM density, and _____ sleep efficiency.
Decreased REM latency
Increased REM density
Decreased sleep efficiency
The boxed warning on AD was based on a review of placebo-controlled short term studies of ___ (#?) of AD. The review found that the risk of suicidal thoughts and behaviors was 2.1% in subjects taking placebo and 3.8% in subjects taking the active medication. FDA black box warning recommends close monitoring of children and adolescents taking SSRI meds for first ___(#?) weeks of treatment.
9 studies
4 weeks
T/F:
Small hippocampal volume has been identified as a risk factor for early-onset depression.
True
