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PHRM2101 > Depression And Anxiety > Flashcards

Depression And Anxiety Flashcards

1
Q

Name the Monoamine Oxidase Inhibitors

A

Phenelzine
Tranylcypromine

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2
Q

Name the SSRIs

A

Citalopram
Escitalopram
Fluoxetine
Fluvoxamine
Paroxetine
Sertraline

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3
Q

Name the SNRIs

A

Desvenlafaxine
Duloxetine
Venlafaxine

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4
Q

Name the TCAs

A

Amitriptyline
Clomipramine
Dosulepin
Doxepin
Imipramine
Nortripyline

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5
Q

Name the benzodiazepines

A

Temazepam
Nitrazepam
Diazepam
Oxazepam
Alprazolam
Bromazepam
Clobazam
Flunitrazepam
Lorazepam
Triazolam

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6
Q

Name the Z-hypnotics

A

Zoldipem
Zopliclone

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7
Q

Name the Non-amphetamine psychostimulants

A

Armodafinil
Modafinil

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8
Q

Name the Psychostimulants used for Narcolepsy

A

Dexamphetamine
Methylphenidate

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9
Q

What is the mechanism of action of SSRI’s?

A

Inhibit serotonin transporters from transporting serotonin from the synaptic cleft back into the presynaptic neuron. Allows for longer effect of serotonin

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10
Q

What is the mechanism of action of SNRI’s?

A

Inhibits serotonin and norepinephrine transporters from transporting their respective neurotransmitters from the synaptic cleft back into the presynaptic neuron. It allows for longer effect of serotonin and norepinephrine.

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11
Q

What is the mechanism of action of TCA’s?

A

Inhibit reuptake of serotonin and norepinephrine into presynaptic terminals. They also block chollinergic, histaminergic, serotonergic and alpha1-adrenergic receptors.

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12
Q

What is the mechanism of action of MAOI’s?

A

Irreversibly inhibits monoamine oxidase from degrading serotonin, noradrenaline, adrenaline and dopamine.
Can cause hypertensive crisis. If taking orally, follow tryamine free diet.

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13
Q

What is the mechanism of action of benzodiazepines?

A

It potentiates the inhibitory effects of GABA throughout the CNS. It has an affinity for all alpha subunits of GABA.

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14
Q

What is the mechanism of action of Z-hypnotics?

A

Interacts with GABA-a receptors containing gamma subunits as a positive allosteric modulator. Improves quality of sleep and reduces sleep onset.

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15
Q

What is the mechanism of action of non-amphetamine psychostimulants?

A

Activates neural circuits that use glutamate as a neurotransmitter while inhibiting GABA activity leading to enhanced excitation while reducing inhibition.
May also reduce dopamine reuptake from synapse.

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16
Q

What is the mechanism of action of psychostimulants?

A

Displaces noradrenaline from synapse in non-regulated and non-vesicular fashion. It drives noradrenaline reuptake transporter in reverse causing the release of noradrenaline. The elavated concentrations lead to inhibition of MAO activity.

17
Q

What is Cataplexy?

A

Triggered by strong emotions, results in a patient not being able to control their muscles.

PHRM2101 (10 decks)

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