Depression Flashcards

1
Q

Characteristics of depression

A
INSADCAGES 
IN – Loss of interest in activities 
S – Sleep disturbances 
A – Appetite change 
D – Depressed mood 
C – Concentration difficulties 
A – Activity level change 
G – Guilt or worthlessness 
E – Energy loss 
S – Suicidal thoughts/ideation
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2
Q

DSM-5 criteria for major depression

A

5 or more present in the same 2-week period

Emotional
Depressed mood
Loss of interest or pleasure

Cognitive
Thoughts of worthlessness or guilt
Diminished concentration/indecisiveness
Suicidal ideation

Somatic
Weight loss or gain
Insomnia or hypersomnia
Fatigue or loss of energy

Behavioural
Psychomotor retardation or agitation

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3
Q

Personal Health Questionnaire (PHQ-9)

A
  • 9 question questionnaire
  • Add up checked boxes to get a score
  • Questions such as ‘little interest or pleasure in doing things’ and ‘feeling tired or having no energy’
  • Score from 0 – 3 with 0 being not at all and 3 being nearly every day
  • 1-4 = minimal depression
  • 5-9 = mild depression
  • 10-14 = moderate depression
  • 15-19 = moderately severe depression
  • 20-27 severe depression
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4
Q

Psychodynamic explanation of depression

A

Freud drew similarities between feelings caused by mourning the death of a loved one and feelings seen in depression
For Freud, depression resulted from a symbolic or actual loss of a loved individual
This loss has a profoundly negative impact on ones’ self-esteem as well as giving rise to feelings of hurt, rejection, disappointment and anger at the individual who is now gone
The feelings of anger result in guilt and self-criticism at having hostile feelings and these trigger depression (Freud, 1916)

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5
Q

Critique of the psychodynamic explanation of depression

A

Some support for low self-esteem being a key feature in depression

Some have emphasised the role of guilt in depressive feelings - children of depressed parents may themselves develop depression due to guilty feelings at their imagined role in the parents depressive state (McWilliams, 1994)

Depression does not inevitably lead on from the loss of a loved relationship and Freud’s theory stems from the analysis of a small number of Viennese women (Dozois, 2000)

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6
Q

Behavioural explanation of depression

A

Lack of social reinforcement plays a role in the development of depression

Lewinsohn (1974) - Social environment and the behaviour of the individual play a role in the development of depression

Social environment – if someone loses their job and has difficulty finding another one then the whole potential for employment-related positive reinforcement is gone

Behaviour – the behaviour of the individual may also contribute to the development of depression if they lack the social skills in order to engage in potentially reinforcing activities

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7
Q

Critique of the behavioural explanation of depression

A

Criticism of this theory have emphasised the lack of solid empirical research to support the model and the lack of consideration of emotional and cognitive factors which play a role in the disorder (Blaney, 1977; Eastman, 1976)

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8
Q

Critique of the behavioural explanation of depression

A

Criticism of this theory have emphasised the lack of solid empirical research to support the model and the lack of consideration of emotional and cognitive factors which play a role in the disorder (Blaney, 1977; Eastman, 1976)

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9
Q

Cognitive explanation of depression

A

People with depression interpret events in a negative way and this leads to a depressive emotional reaction
Example, someone who is unsuccessful at a job interview may blame themselves for their situation and believe that they will fail at any attempt to find work
They may also feel that any initiative to do with work, social life or romance may be destined to fail
(Ellis, 1993)

Individuals with depression focus on negative events (Gotlib & Joormann, 2010)

Pessimistic outlook stems from childhood experiences which are categorised by negative parental interactions (Renner et al., 2012)

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10
Q

Beck (1967) negative cognitive triad

A

Negative cognitive triad (negative view of self, the world and the future)
Leads to cognitive biases, then to failure, losses and depression
Depression results from distorted thoughts and judgements
Can be learned socially as is the case when children in a dysfunctional family watch their parents fail to successfully cope with stress
Or can results from a lack of experience that would normally lead to the development of adaptive coping skills
Diathesis-stress model

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11
Q

Beck types of faulty thinking

A
Beck et al., (1987) identified several types of faulty thinking that are present in depression 
•	Overgeneralising 
•	Selective abstraction 
•	Dichotomous thinking 
•	Personalisation 
•	Catastrophising
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12
Q

Learned helplessness

A

When dogs were given electric shocks, which were unavoidable, they learned that there was no escape and passively accepted the shocks, despite the discomfort (Seligman, 1965)
Demonstrated this in undergraduates and theorised that depression arises when individuals believe they have no control over their physical or social environment (Seligman, 1975)

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13
Q

Environmental factors in the development of depression

A

Environmental stressors have been linked to the onset, prolongation and reoccurrence of depression both for acute stress and chronic stress (Hammen et al., 2009)

Stress experienced in childhood leads to more severe depression (Lara et al., 2000)

Not all types of stress lead to depression – stress involving loss, social rejection or humiliation are more likely to lead to depression than stress due to dangerous situations (Kendler et al., 2003)

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14
Q

Environmental protectors from depression

A

Environmental protectors for depression = familial support, financial support and participation in sport (Babiss & Gangwisch, 2009)

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15
Q

Genetic predisposition in depression

A

Incidence of first-degree relatives of those with depression have an almost 3-fold risk compared to the general population (Hettema, 2010)

Concordance rate of between 16-35% in dizygotic twins compared to 70-90% in monozygotic twins (Sadock & Sadock, 2007)

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16
Q

Serotonin transporter genes in depression

A

Implicated an abnormality in the serotonin transporter gene (5-HTTLPR) which plays a role in the availability of serotonin, strong evidence that this genetic abnormality increases the risk of people developing depression when under stress (Karg et al., 2011)

17
Q

Dopamine receptor genes in depression

A

Has been suggested that the DRD4 gene which encodes the dopamine D4 receptor is faulty in depressive patients (Hettema, 2010)

18
Q

Critique of gene studies

A

Gene studies in general are limited by an incomplete understanding of the precise pathophysiology of depression and low subject numbers

19
Q

Neurotransmitter systems

A

It was first discovered that neurotransmitters may play a role in depression when the drug reserpine, a treatment for hypertension, was found to have depressive side effects. This drug depletes the amounts of monoamine neurotransmitters including serotonin and noradrenaline. A compound called iproniazid, which increased the neurotransmitters in the system was found to elevate mood (Slattery et al., 2004)

20
Q

Monoamine hypothesis

A

Depression results from insufficient quantities of serotonin and noradrenaline

21
Q

Critique of the monoamine hypothesis

A

(Hirschfield, 2000)
Monoamine levels are increased rapidly on antidepressant medication, yet the therapeutic effects take at least two weeks
Some compounds increase serotonin or noradrenaline and do not produce antidepressant effects

22
Q

Cortisol levels in depression

A

When an individual is under stress the body releases cortisol which forms part of the fight or flight response and causes physiological arousal and anxiety
Individuals with depression have higher levels of cortisol (Young, 2004)

Increased and prolonged reactivity to stressors may deplete neurotransmitter systems, particularly serotonin (Leonard, 2010)

23
Q

Circadian rhythms in depression

A

Disturbances in circadian rhythms have been observed in depressed patients with the majority having trouble falling asleep, staying asleep or waking early in the morning
Depressed patients have increased REM sleep and decreased slow-wave sleep
Proposed that the central regulator that controls circadian rhythms is dysfunctional in depression and this contributes to the symptoms experienced (Germain & Kupfer, 2008)

24
Q

What is a circadian rhythm?

A

Circadian rhythms are the cyclical physiological changes that occur within an organism over a repeated time period eg our sleep wake cycle

25
Q

Neuroanatomical factors

A

Reduced activity in the prefrontal cortex which may be due to a reduced volume of this brain area in depression (Davidson et al., 2002)
Suggested that one of the roles of the prefrontal cortex is to control fear responses originating in the limbic system, particularly the amygdala. If this control is not exercised fully, then fear responses which are a feature of depression will be manifest (Arnsten, 2009)

Evidence that the hippocampus is reduced in size in depression (Malhi & Lagopoulos, 2008)
Aspects of memory that are impaired in depression e.g. recollection memory are mediated in the hippocampus (Campbell & MacQueen, 2004)

26
Q

Critique of neuroanatomical factors

A

Drawing firm conclusions of neuroanatomical irregularities in depression is difficult because it is impossible to tease apart any effect of medication from an effect of the disorder itself

It is also difficult to distinguish between irregularities which may be symptom related and transient, or those which may provide a stable biological marker of the illness (Malhi & Lagopoulos, 2008)

27
Q

Global Burden of Disease Study (2003)

A

Depression is the predominant mental health problem worldwide
Depression was the second leading cause of years lived with disability worldwide

28
Q

Adult Psychiatric Morbidity Survey (APMS)

A

Provides data on the prevalence of both treated and untreated psychiatric disorders in the English adult population
Robust, stratified, multi-stage probability sample of households and assesses psychiatric disorder to actual diagnostic criteria for a number of disorders

29
Q

Lifetime prevalence of depression in the general population

A

Lifetime prevalence in the general population has been estimated to be 16.2% based on 9000 Americans (Kessler et al., 2003)

30
Q

Beck’s depression inventory

A

Beck (1961)
21 question, multiple choice, self-report inventory
Most widely used psychometric test for measuring depression

31
Q

Limitations of Beck’s depression inventory

A

Score can easily be exaggerated or minimised
Environment the test is taken in can effect the scores - a clinical environment will elicit different scores than if it is taken in the home