Depression Flashcards
WHat are the symptoms?
- Cognitive : trouble concentrating and making decisions
- behavioural: social withdrawal
- somatic (physical) - insomnia/ hypersomnia
- affective - sad
what are the subtypes
reactive
endogenous
unipolar
bipolar
gentics
60% monozygotic
15% disygotic
Brown - environment
84% of depressed patients had experienced stress in the previous year
32% of the control also had severe stress in previous year but no depression.
What is the primary model of depression
The diathesis stress model
how do MAOI’s work
They break down the enzyme which breaks down monamine neurotransmission which results in more neurotransmitters in the synapse.
What are tricyclic antidepressants?
They slow the rate of re uptake of serotonin and norephinphrine.
But unwanted side effects - weight gain, dry mouth, constipation, drowsiness and dizziness.
What are monamines ?
Epinephrine, norepinephrine and serotonin
What are SSRIs
more selective that TCAs, they mainly work on serotonin.
a type of SSRI is prozac
What is used to treat bipolar
lithium.
Theories of depression
antidepressants act on monamines therefore depression results from a deficit in monamine neurotransmitters : Serotonin, norephinephrine and epinephrine.
