Dentine Caries Flashcards

1
Q

What is the structural composition of dentine?

A
  • 70% inorganic
  • 20% organic
  • 10% water
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2
Q

What do odontoblasts differentiate from?

A

Differentiate from cells of dental papilla

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3
Q

What do odontoblasts secrete? How do these help in the formation of mantle dentine?

A

Odontoblast process secretes HAP crystals that mineralize collagen matrix

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4
Q

How are dentine tubules linked to odontoblasts?

A

Dentine tubules contain cytoplasmic processes of odontoblasts

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5
Q

What is the width of the dentine tubules at

Pulp?
EDJ?

A
  • Widest near pulp 2.5µm

- Narrowest at EDJ 0.9µm

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6
Q

Describe the location of the dentine tubules

A

Extend from odontoblast layer at pulp to enamel-dentine junction

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7
Q

Primary dentine;

When is it laid down?
Dentine-pulp complex response?

A
  • Laid down in dentinogenesis

- Normal dentine-pulp complex response

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8
Q

Secondary dentine;

When is it laid down?
Dentine-pulp complex response?

A
  • Laid down throughout life

- Normal dentine-pulp complex response

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9
Q

Tertiary dentine;

When is it laid down?
Dentine-pulp complex response?

A
  • Laid down in response to noxious stimuli

- ‘Altered’ dentine-pulp complex response

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10
Q

What occurs to lesions during late enamel caries?

What response is initiated?

A

Progressing legions approach EDJ, which initiates defensive dentine pulp reactions

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11
Q

What occurs to lesions during dentine caries?

A

Lesions crosses EDJ and spreads into dentine

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12
Q

Why is there lateral spread at the EDJ for dentine caries? (3)

A
  • Dentine mantle is hypo mineralised
  • Increased side branching of tubules
  • Defects within tissues of EDJ
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13
Q

When can you no longer reverse dentine caries?

A

Infected dentine tubules cause proteolytic dissolution

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14
Q

Explain clinically what a caries infected zone is

Appearance?
Mineral components?
Collagen?
Bacterial load?
Dentine tubules?
A
  • Dark brown, soft, wet, ‘mushy’
  • Mineral component dissolution
  • Collagen matrix denatured
  • High bacterial load
  • Dentine tubules destroyed
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15
Q

Explain clinically what a caries affected zone is

Appearance?
Mineral components?
Collagen?
Bacterial load?
Dentine tubules?
A
  • Sticky, scratchy, leathery
  • Mineral component dissolution (lesser degree)
  • Collagen matrix damaged by proteolysis but not denatured
  • Lower bacterial load
  • Dentine tubules remnants intact
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16
Q

What does the dentine-pulp complex do?

A

Excrete dentine in response to injury

17
Q

What are the two types of tertiary dentine?

A
  • Reactionary dentine

- Reparative dentine

18
Q

What is the role of peritubular dentine in the dentine pulp complex to stop the progression of carious lesions?

A

Peritubular dentine occludes cut dentine tubules which prevents further injury

19
Q

Reactionary dentine;

Where is it laid down?
What does it do?
Response to what severity of stimulus?
Fate of odontoblasts?

A
  • Tertiary dentine laid down at dentine-pulp interface
  • Increases distance between dentine-pulp and stimulus
  • Low grade stimulus
  • Odontoblasts survive
20
Q

Reparative dentine;

Where is it laid down?
What does it do?
Response to what type of stimulus?
Fate of odontoblasts?

A
  • Tertiary dentine laid down at dentine-pulp interface
  • Increases distance between dentine-pulp and stimulus
  • Higher grade stimulus
  • Odontoblasts vitality compromised (become dead cells)
21
Q

Which tertiary dentine type is deposited quicker once stimulated?

A

Reparative is deposited much faster than reactionary

22
Q

What dental condition does noxious stimuli lead to for the pulp?

A

Noxious stimuli leads to inflammation of pulp (Pulpitis)

23
Q

Slow progressing lesions;

Type of pulpitis?
Cellular changes?
What cells begin to arise?

A
  • Chronic Pulpitis
  • Fibrosis within pulp
  • Plasma Cells and Lymphocytes arising