DENT 1050 Test #1, Chapters 4 and 5 Flashcards
Radiation injury; All radiation is:
harmful and produces biologic changes in living tissue
Radiation injury; Free radical formation:
i. Primary form of damage x-radiation causes
ii. Occurs when an x-ray ionizes water
1. Results in hydrogen and hydroxyl free radicals
Free radical
an uncharged (neutral) atom or molecule that exists w/a single, unpaired electron in its outermost shell; highly reactive and unstable
To achieve stability, free radicals do 1 or 3 things:
a. Recombine w/o causing changes in the molecule
b. Combine w/ other free radicals and cause changes
c. Combine w/ ordinary molecules to form a toxin - damaging
Direct Theory of radiation injury
Cell damage results when ionizing radiation directly hits critical areas within the cell (DNA) - occurs infrequently
Indirect Theory of radiation injury
X-ray photons are absorbed w/in the cell and cause the formation of toxins which in turn damage the cell via free radicals;
i. greater chance of free radical formation because cells are 70-80% water
ii. actual damage done is BY the free radicals, ions and toxins, NOT the actual x-ray
Dose-Response Curve
used to correlate the “response” or damage of tissues w/the dose or amount of radiation received
Linear relationship of dose-response curve
response of the tissues - damage - is directly proportional to the dose
Nonthreshold relationship of dose-response curve
a threshold dose level for damage doesn’t exist; do not need a certain dose for damage to occur; NO absolute SAFE amount of radiation exposure
Radiation Injury Sequence, Repair & Accumulation
Latent period, period of injury, recovery period, cumulative effects
Latent Period of radiation injury
the time that elapses between exposure to ionizing radiation and the appearance of observable clinical signs; the more radiation received and the faster the dose rate -> the shorter the latent period
Period of injury of radiation injury
follows the latent period when cells show damage
Recovery period of radiation injury
depending on a number of factors, cells can repair the damage caused by radiation (if allowed time to repair)
Cumulative effects of radiation injury
the effects of radiation exposure are additive and damage that remains unrepaired accumulates in the tissue
Determining factors for radiation injury
Total dose, dose rate, amount of tissue irradiated, cell sensitivity, age
Determining factors: Total dose
quantity of radiation received
Determining factors: Dose rate
dose/time; more damage takes place with high dose rates b/c a rapid delivery of radiation doesn’t allow time for the cellular damage to be repaired
Determining factors: Amount of tissue irradiated
extensive radiation injury occurs when large areas of the body are exposed because of the damage that occurs to the blood-forming tissues (nuclear energy disaster)
Determining factors: Cell sensitivity
rapidly dividing, young cells are more adversely affected
Determining factors: Age
children are more susceptible to radiation damage than adults
Radiation effects: Short-term
a. seen within minutes, days or weeks
b. large amounts of radiation absorbed in a short amount of time
c. Acute Radiation Syndrome (ARS)
d. rarely seen in dentistry
Acute Radiation Syndrome (ARS)
includes nausea, vomiting, diarrhea, hair loss, hemorrhage
Radiation effects: Long-term
a. appear after years, decades or generations
b. Associated w/small amounts of radiation absorbed repeatedly over a long period of time
c. linked to induction of cancer, birth abnormalities and genetic defects
Radiation effects: Somatic effects, somatic cells
- ALL THE CELLS IN THE BODY EXCEPT REPRODUCTIVE CELLS
i. somatic effects; seen in the person irradiated
ii. cell changes are NOT transmitted to future generations
Radiation effects: Genetic effects, genetic cells
- REPRODUCTIVE CELLS: OVA & SPERM
i. genetic effects: NOT seen in the person irradiated, but are passed on to future generations
ii. genetic damage can NOT be repaired