Dementia with Lewy Bodies Flashcards
1
Q
How do patients with Dementia with Lewy bodies typically present?
A
Dementia
Masklike faces
Rigidity and flexed posturing
Tremor
Short shuffling gait
Parkinsonian motor disturbances
Visual hallucination are hallmark
2
Q
What is the basic pathophysiology underpinning Dementia with Lew bodies?
A
Lewy bodies in Substania nigra, as well as other brainstem nuclei and cortex.
Lewy bodies are abnormal aggregates of synaptic protein alpha-synuclien.
