Dementia vs Delirium Flashcards
Define dementia
Major neurocog disorder
- acquired disorder characterized by decline in cognition involving 1+ cognitive domains
Define mild cognitive impairment
Mild neurocog disorder
- state between normal cognition and dementia where functional abilities are preserved, but can be a precursor to dementia
Define delirium
- problem with attention, awareness, develops over short period of time
- triggered by wide variety of chonditions
- days to months long
Define encephalopathy
medical diagnosis characterized by symptoms of delirium, confusion, AMS, secondary to many things like stroke, hypoglycemia, seizure, infection, substances, etc. (ie: septic encephalopathy from a UTI)
Describe the 5 key features of delirium in the DSM 5
- disturbance in attention and awareness
- short period of time
- additional cognitive disturbances
- not explained by established/evolving neurocog disorder
- evidence that it is secondary to a physiologic consequence
Explain the consequences of delirium
- increases risk of death within a month
- length of hospital stay doubled
- increased risk of complications
- increased risk of dementia
- 2x risk of RN home need
Describe the pathophys of delirium
- systemic trigger (inflammation, hypoxemia)
- vulnerabilities exacerbated (neuronal damage, vascular dysfunction, astrocyte/microglia degeneration)
- cause cellular and functional changes leading to neuronal dysfunction, immune cell infiltration, metabolic insufficiency
- lead to delirium
List some premorbid factors for delirium
- age
- dementia
- low education
- high comorbidity burden
- frailty
- tethers to bed
Describe hypoactive vs hyperactive delirium
How to diagnose symptoms of delirium
DSM 5 but more commonly the CAM (confusion assessment method)
CAM
- acute onset of mental status change or fluctuations and
- inattention and
- disorganized thinking or
- altered consciousness (anything other than alert)
How can delirium be prevented
through delirium prevention protocols that systemically address risk factors (ABCDEF ICU bundle)
- there are no pharm interventions that decrease risk indefinitely (pain, symptom management can help)
How to reduce risk of delirium
mitigate risk factors
How to manage delirium
- identify and reverse potential reversible triggers
- correct physiologic disturbances
- engage family and other support
- antipsychotics (olanzepine, haloperidol) off label as last resort - can exacerbate elderly with dementia or increase rate of death
How does the DSM define dementia
- significant cognitive decline in 1+ cognitive domains
- interference with ADLs
- not exclusively during delirium
- not better explained by another mh disorder
What are some of the types of dementia
- Alzheimer’s (60-80%)
- cerebrovascular disease
- frontotemporal
- dementia with lewy body
- Parkinsons
- Huntingtons
- can have mixed types
- etc.