Dementia Flashcards
what are four changes seen in delirium?
altered level of consciousness
illusions/hallucinations
disturbed sleep/wake cycle
aletered psychomotor activity
what are top culprits of elderly delirium?
meds
infection
metabolic disturbance
what it top culprit in young for delirium?
intoxification or withdrawal
what is pathology of delirium?
just something to do with release of cytokines in brain and altered Nts
what is mild cognitive impairment defined as?
a loss in memory
how many cognitive domains change in mild cognitive impairment?
only loss of memory
how many cognitive domains are affected by dementia?
multiple
what must dementia interfere with?
work or social life
in a neurodegenerative disorder, what must there by loss of?
neurons
what leads to the pathology of neurodegenerative disorders usually?
deposition of abnormal proteins in the brain
what are the three important proteins affiliated with neurodegenerative disorders
amyloid, tau and alpha synuclein
what are two common findings in alzheimers on patho?
plaques and tangles
what is most common form of neurodegnerative dementia?
alzheimers
what are alzheimers plaques filled with?
often have beta amyloid core
how does gross brain look in alzheimers?
atrophy of cortices widespread with thinning of gyri and widening of sulci
what are the tangles filled with in alzheimers?
tau protein
what is frontotemporal dementia?
dementia only affecting frontal and temporal portions
what is change seen in frontotemporal dementia?
marked personality changes like disinhibition, apathy, loss of insight and emotional control