Dementia

Question 1

What are the genes involved in Fronto Temporal dementia?

Answer 1

– Tau gene
– Progranulin gene

Question 2

What are the findings on CT/MRI of a patient with Fronto Temporal dementia?

Answer 2

Temporal lobe atrophy
Frontal lobe atrophy

Question 3

Pathogenesis of alzheimer disease

Answer 3

Extracellular deposition of
. beta amyloid protein
. Neurofibrillary tangles containing tau protein.

Question 4

EEG in Alzheimer shows….

Answer 4

Loss of alpha rhythm

Question 5

CSF findings of alzheimer disease

Answer 5

detection of lower
concentrations of Aβ1–42 and higher concentrations of
tau

Question 6

MRI findings in alzheimer disease

Answer 6

bilateral hippocampal atrophy (temporal lobe)

Question 7

Management of alzheimer disease

Answer 7

• Cholinesterase inhibitors
– donepezil, rivastigmine,
galantamine
• Memantine

Question 8

Treatment of mild to moderate alzheimer disease

Answer 8

Cholinesterase inhibitors : Rivastigmine, galantamine, donepezil

Question 9

Tx of moderate alzheimer disease

Answer 9

Memantine

Question 10

Tx of severe alzheimer disease or milder froms who cannot take Cholinesterase inhibitors

Answer 10

Non-competitive N M D A receptor antagonist

Question 11

Management of dementia with Lewi bodies

Answer 11

Anticholinesterase

Question 12

Thalamic (pulvinar)
‘hockey stick’ sign is present in which disease?

Answer 12

Prion disease–
‘classical’ Creutzfeldt Jakob disease (CJD)