Definitions Flashcards
Virion?
mature infectious virus particle.
capsid?
protein shell that encloses and protects the viral nucleic acid.
Nucleocapsid?
the internal part of the virus particle, which consists of the nucleic acid and closely associated capsid proteins.
Envelope?
the viral membrane, consisting of a lipid bilayer, proteins, and glycoproteins. derived from the host cell membrane
+ssRNA?
single stranded RNA of the same polarity as mRNA.
-ssRNA?
single stranded RNA complementary to mRNA. Opposite strand (don’t code with it) have to make a copy
DNA dependent RNA polymerase?
an enzyme that uses DNA as a template for producing RNA (your cells use this to transcribe genes).
RNA dependent RNA polymerase?
an enzyme that uses RNA as a template for producing RNA (viruses use this to make mRNA and RNA genomes, not present in host). Unique to viruses. Brings this with them
Transfection?
infection of mammalian cells by bare viral nucleic acid.
Transformation (in virology)?
a stable heritable change in the genetic makeup and phenotype of a cell resulting from the infection of that cell by a virus. (Usually implies converting to a neoplastic phenotype.)- changing cells to a neoplastic state (viruses use this to replicate) more with DNA viruses
permissive cell?
cells that support the complete virus life cycle, with production of infectious virus particles.
nonperissive cells?
cells-cells which permit none of or only part of the virus life cycle. Often nonpermissive cells are transformed by viruses. Applies especially to DNA viruses.
Defective virus?
a virus that is not capable of going through its entire replication cycle unless the cell is infected with a complete virus (helper) particle as well. Used in labs
Hep D needs Hep B
Cytopathic effect (CPE)?
observable damage to a cell resulting from virus infection.
