Definitions Flashcards

1
Q

Agonist

A

A drug that binds to a receptor and activates it

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2
Q

Antagonist

A

A drug that binds to a receptor and produces no response

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3
Q

Affinity

A

the attraction of a drug for a receptor

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4
Q

Efficacy

A

describes how well the drug elicits a response once bound to the receptor

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5
Q

Intrinsic activity

A

the capacity of a single drug-receptor complex to evoke a response

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6
Q

Full agonist

A

produces maximum response; high efficacy

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7
Q

Partial agonist

A

cannot achieve maximum response; lower efficacy

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8
Q

Inverse agonist

A

decreases receptor activity

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9
Q

Reversible antagonist

A

binds then dissociates; may compete with agonist for binding site; surmountable;
remember competitive antagonism

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10
Q

Irreversible antagonist

A

binds and dissociates very slowly; not surmountable; inactivates a proportion of the receptor population

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11
Q

Competitive antagonist

A

binds to the receptor at the same site the agonist uses; also can alter shape of receptor when bound to make it inaccessible to the agonist

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12
Q

Non-competitive antagonist

A

binds to receptor only when agonist is not bound

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13
Q

Uncompetitive antagonist

A

binds to the receptor even when the agonist is bound

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14
Q

Potency

A

the concentration of drug required to produce a certain response

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15
Q

EC50

A

is the concentration of drug required to produce 50% of a maximum response

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16
Q

Tachyphylaxis

A
17
Q

pharmacodynamic tolerance

A

gradual downregulation of receptors (long-term opioid abuse)

18
Q
A