Decongestant and Anti-Tussive Pharmacology Flashcards
1
Q
guaifenesin is an example of
A
- expectorant
2
Q
MOA of guaifenesin
A
- reduces viscosity of mucus
- inhibit parasympathetic stimulation of mucus secretion
3
Q
N-acetylcysteine is an example of
A
- mucolytic
4
Q
MOA of mucolytics
A
- reduces disulfide bonds to degrade mucin
5
Q
how is N-acetylcysteine administered?
A
- by inhalation
6
Q
what is Benzonatate
A
- peripherally activating anti-tussive
7
Q
MOA of benzoate
A
- Na+ channel blocker
8
Q
what is Dextromethorphan
A
- centrally acting anti-tussive
9
Q
Dextromethorphan MOA
A
- glutamate antagonist
- blocks cough center through medulla
10
Q
toxicities of dextromethorphan
A
- dissociative effects
- potential for abuse
11
Q
what is codeine
A
- centrally-active antitussive
12
Q
what drug do we often combine codeine with
A
- promethazine
13
Q
MOA of codeine
A
- inhibits Ca2+ influx and neutrotransmitter release in presynaptic neuron
- stimulates K+ effects and hyper polarization in postsynaptic neuron
14
Q
MOA of pseudoephedrine and phenylephrine
A
- alpha 1 agonists
- vasoconstriction
- reduce nasal mucous membrane swelling
15
Q
what else can we also use phenylephrine to treat
A
- hemorrhoids
