All Zanki Final Stuff - Pathology Flashcards
Acute respiratory distress syndrome is a cause of _____ lung disease
- interstitial lung disease
Allergic bronchopulmonary aspergillosis is usually seen in individuals with
- asthma
- cystic fibrosis
An EGFR “driver mutation” is especially common in [race] female [smoking status] who have adenocarcinomas of the lung
- asian female nonsmokers
Asthma is often associated with _______, ________ and a family history of ________
- allergic rhinitis
- eczema,
- atopy
Asthma may present with a(n) […] inspiratory/expiratory ratio
- decreased
- prolonged expiration
Asthma may present with ________ on CXR
- peribronchial cuffing
diagnostics of ARDS
- Abnormal CXR
- Respiratory failure within 1 week of insult
- Decreases PaO2/FiO2 ratio
- Symptoms not due to Heart Failure
Because the facial vein is valveless, infections of the face can spread to the […]
- cavernous sinus
Berylliosis is characterized by a […] histology and therefore is occassionally responsive to treatment with steroids
- granulomatous
Bronchial carcinoid tumor is characterized histologically by nests of […] differentiated _________ cells
- well
- neuroendocrine
Bronchiectasis is due to chronic […] inflammation or obstruction which results in permanently dilated airways
- necrotizing
Bronchopneumonia is often multifocal and […] (uni- or bilateral)
- bilateral
central sleep apnea is treated with
- positive airway pressure
Central sleep apnea may be also caused by delayed detection / response to changes in […] resulting in cyclic (…) breathing
- PaCO2
- Cheyne-Stokes
Cheyne-Stokes breathing is defined by respirations that oscillate between […] and […] in response
- apnea
- hyper apnea
Chronic bronchitis and bronchiectasis in a cystic fibrosis patient leads to a […] pattern on CXR
- reticulonodular
Chronic bronchitis is associated with […], due to early-onset hypoxemia from shunting
- cyanosis
Chronic complications of emphysema include […] (due to destruction of capillaries in the alveolar sac) with eventual cor pulmonale
- hypoxemia
Clinical features of emphysema include dyspnea and cough with […] sputum production (quantity)
- minimal
Bronchiectasis is due to chronic necrotizing inflammation or […] which results in permanently dilated airways
- obstruction
Complications of bronchiectasis include secondary
[…] and hypoxemia with
cor pulmonale
- amyloidosis
Compression / neuropathy of the phrenic nerve results in […] inspirations during maximal voluntary ventilation
- uniform weak (like always weak)
Consolidation (lobar pneumonia, pulmonary edema) may present with late inspiratory ______________ (sound heard on lung exam)
- crackles
Consolidation (lobar pneumonia, pulmonary edema) presents with ________ fremitus
- increased
COPD patients with oxygen induced hypercapnia suffer from excess oxygen induced generation of increased […]
- physiologic dead space
Cystic fibrosis may present with […] (volume)_____ (pH)
- contraction
- alkalosis
Cystic fibrosis may present with […]natremia
- hypo
buzzwords for Wegener’s
- necrotizing
- granulomatous
- vasculitis
Death from a saddle pulmonary emboli is due to […] dissociation
- electromechanical
during what days does red hepatization occur
congestion phase
gray hepatizaiton
- days 3-4
- days 1-2
- days 5-7
Emphysema is characterized by loss of […], which inhibits the ability to exhale air from the alveoli (air trapping)
- elastic recoil
Emphysema is characterized by […] of air spaces
- enlargement
Endothelial dysfunction of the pulmonary vasculature results in increased […] and decreased […]
- increased vasoconstrictors
- decreased vasodilators
Granulomas due to sarcoidosis may have […] bodies, which are calcium and protein inclusions inside of giant cells
- Schaumann
In an asthmatic response, inflammatory mediators, especially […] from eosinophils, damages cells and perpetuates bronchoconstriction (late-phase reaction)
- major basic protein
DLCO in asthma
- chronic bronchitis
- emphysema
- normal or elevated
- normal
- decreased
In cystic fibrosis, increased intracellular Cl- results in compensatory increased Na+
[…] via epithelial Na+ channels
- reabsorption
In patients with long standing COPD, the main contributor to respiratory drive is arterial […] levels
- PaO2
In ARDS, activation of […] by proinflammatory cytokines induces free radical and protease-mediated damage of both type I and II pneumocytes
- neutrophils
Infections in the sphenoid or ethmoid sinus may extend to the […] sinus and cause complications
- cavernous
Inflammation in the lung normally leads to release of […] by neutrophils and macrophages
- proteases
Is bronchial carcinoid tumor related to smoking?
no
Is large cell carcinoma related to smoking?
- yes
Klebsiella pneumoniae is often complicated by […] formation in the lungs and liver
- abscess
Large cell carcinoma is characterized histologically by […] differentiated large cells
- poorly
Laryngeal papillomas may have […] change on biopsy
- koilocytic
Laryngomalacia presents with __________ during infancy due to collapse of […] during inspiration
- inspiratory stridor
- supraglottic tissues
Lower limb DVT may be associated with […] upon dorsiflexion of the foot (Homan sign)
- calf pain
Lung abscess commonly occurs in patients predisposed to […] (e.g. alcoholics, epileptics)
- loss of consciousness
Lung abscesses may present with […] on CXR, which suggests _______
- air-fluid levels
- cavitation
Lung […] is a localized collection of pus within the parenchyma
- abscess
Malignant otitis externa is an emergency that can progress to osteomyelitis of the […]
- skull base
Malignant otitis externa is most commonly seen in the […] population
- diabetic
Many patients with inhalation injury present secondary to […], ____ inhalation, _______ poisoning, or _______ poisoning
- burns
- CO
- cyanide
- arsenic
Mesothelioma presents with recurrent […], dyspnea, and chest pain
- pleural effusions
Mild exposure to carbon (e.g. pollution) results in […], which is an asymptomatic condition characterized by collections of carbon-laden macrophages
- anthracosis
Most pulmonary emboli arise via a thromboembolus from the proximal […] of the lower extremity
- deep veins
Mutant α1-antitrypsin polymerizes and accumulates in the […] of hepatocytes, resulting in liver damage (e.g. cirrhosis)
- endoplasmic reticulum
Nasal polyps are associated with _______________ in adults
- aspirin intolerant asthma
Nasopharyngeal carcinoma often presents with involvement of ________ lymph nodes
- cervical
Neonatal respiratory distress syndrome is associated with diffuse granularity of the lung with a “[…]” appearance on CXR
- ground glass
Obstructive sleep apnea is associated with difficult to manage […] due to increased sympathetic tone
- systemic hypertension
Obstructive sleep apnea is due to relaxation of […] during sleep
resulting in
- pharyngeal muscle tone
- closure of upper airway, decline PO2 and increased PCO2
Obstructive sleep apnea may be caused by excess […] tissue in adults (age group)
- parapharyngeal
Obstructive sleep apnea may be caused by […] hypertrophy in children (age group)
- adenotonsillar
Most pulmonary emboli arise via a thromboembolus from the […] deep veins of the lower extremity
- proximal
Obstructive sleep apnea is associated with difficult to manage systemic hypertension due to increased […]
- sympathetic tone
One complication of Mycoplasma pneumoniae is autoimmune […] due to high concentrations of cold agglutinins (IgM)
- hemolytic anemia
One multifactorial cause of secondary pulmonary hypertension is due to _______ of the pulmonary vasculature by ______
- compression
- tumor
One test for fetal lung maturity is the _____:_____ ratio in the amniotic fluid
- surfactant
- albumin
Pancoast tumors may cause […] syndrome, which is characterized by shoulder pain, Horner syndrome, atrophy of hand/arm muscles, and edema (due to vascular compression)
- Pancoast
Pathogenesis of asthma involves allergens inducing a TH[…] phenotype in CD4+ T cells of genetically susceptible individuals
- TH2
Patients who develop pulmonary infarction may develop right heart strain that generates a ______ EKG finding
- S1Q3T3
Patients with long standing COPD who are administered excessive oxygen can develop […]
- hypercapnia
Patients with sarcoidosis may have scattered granulomas in their liver; most commonly affecting the […]
- portal triads
Pleural effusion causes restricted lung […] (inspiration or expiration)
- inspiration