deck_4765807 Flashcards
IL-7
B cell growth factor produced by bone marrow stream cells during development. No IL-7= normal no. of B cells, but they are non-functional
C5a
Chemotactic factor for neutrophils and promotes activation of AA pathway in inflammation
How can C5a be produced?
via C5 convertase and Thrombin (think Hageman pathway)
CR2
Co-receptor on B cells that can bind C3b and when engaged amplifies the 1st activation signal to B cells (remember that the transduction of the first activation signal requires engagement of multiple BCRs so having CR2 engaged lessens the amount needed)
IL-8
Chemotactic factor for neutrophils from classical macrophages
IL-1
1) Activates fibroblasts in chronic inflammation and tissue repair2) Locally activates vascular endothelium to up regulate E and L selection and ICAM expression, activates lymphocytes, induces platelet adhesion to activated endothelium to prevent dissemination of bacteria 3) Upregulates IL-6 production in the liver4) Systemically causes fever by activating the AA pathway (specifically PGE2)Extra: Increases insulin resistance in skeletal muscle (with TNF-a) in chronic inflammation
IL-12
1) made by macrophages and locally activates NK cells to fight viral infection2) produced by APCs to promote differentiation of THO to TH1 (along with IFN-y)
CXCL8
made by macrophages and similar to IL-8 in acting as a neutrophil and basophil attractant
TNF-a
Made by TH1, TH2, CTLS, and macrophages 1) Locally activates vascular endothelium to up regulate E and L selection and ICAM expression, activates lymphocytes, induces platelet adhesion to activated endothelium to prevent dissemination of bacteria 2) Systemically induced fever (similar to IL-1)3) when made by TH1, TH2, or CTLs induce macrophages to make NO
IL-6
Systemically induces fever by acting on hypothalamus and activates acute phase PRRS from liver (CRP, MBP, Fibrinogen, SAA protein)
MIC
upregulated in virally-stressed cells and induce degranulation of NK cells remember expression of MHC I prevents this
IFN-a/B
Induces up regulation of MHC I on non-virally infected cells to prevent Nk activation and helps NK cells to act when appropriate
CD10/CD19/CD20
lymphoid progenitor cell surface marker that can be used to diagnosis C-ALL and B-ALL
CD-1
thymocyte surface marker used to diagnosis T-ALL
CD34
hematopoietic stem cell surface marker