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MI Exam 3 > Deciding what vector is best for gene therapy > Flashcards

Deciding what vector is best for gene therapy Flashcards

1
Q

Uses double stranded DNA

A

Adenovirus and Herpes Simplex virus

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2
Q

Uses single stranded DNA

A

Adeno-Associated Virus

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3
Q

Uses RNA

A

Retrovirus

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4
Q

Retrovirus EG

A

HIV

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5
Q

Adenovirus EG

A

Common cold

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6
Q

Adeno-associated virus EG

A

Nonpathogenic

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7
Q

Herpes Simplex virus EG

A

Oral/genital herpes

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8
Q

Infects neurons and the nervous system only

A

Herpes simplex virus

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9
Q

Only infects dividing cells

A

Retrovirus

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10
Q

Infects dividing and nondividing cells

A

Adenovirus and Adeno-associated virus

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11
Q

Remains in cells as plasmid DNA

A

Herpes simplex virus

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12
Q

No immune response

A

Adeno-associated virus

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13
Q

Max insert size 5k base pairs

A

Adeno-associated virus

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13
Q

Max insert size 5k base pairs

A

Adeno-associated virus

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14
Q

Max insert size 8k base pairs

A

Retrovirus

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14
Q

Max insert size 20k base pairs

A

Herpes simplex virus

15
Q

Max insert size 7.5k base pairs

A

Adenovirus

16
Q

Can cause immune response, possible to reduce chance

A

Retrovirus, Herpes Simplex Virus, Adenovirus

17
Q

Integrates randomly

A

Retrovirus

18
Q

Can be engineered to recognize specific proteins or tissue types

A

Retrovirus, Adenovirus, Adeno-associated virus

19
Q

Integrates into Chromosome 19 95% of the time

A

Adeno-associated virus

20
Q

DNA is transient

A

Adenovirus

21
Q

Requires a “helper” virus to be replicated

A

Adeno-associated virus

MI Exam 3 (11 decks)

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