DDX Flashcards
DDX Hypercalcemia (6)
- Primary hyperparathyroidism
- Increased Bone turnover
- Hyperparathyroid
- Immobilization
- Vit A intoxication- Thiazide diuretics
- Renal failure
- Familial Hypocalcuuric hypercalcemia
- Malignancy
a. Metastatic like breast Ca
b. PTH related (lung/kidney Ca)
c. Hematologic (MM, Leukemia) - Vit D related
a. Vitamin D intoxicaton
b. Granulomatous disease
i. TB
ii. Sarcoid
DDX Hypothyroidism (7)
Primary
- Thyroiditis: Hashimoto, post partum, irradiation
- Drugs: lithium, ASA, PTU
- Iatrogenic: Post ablative Graves/surgery
- Iodine deficiency
- Congenital: thryroid dysgenesis
Secondary
- Pituitary (tumor, Sheehans syndrome)
- Hypothalamic
DDX Dyslipidemia (8)
Primary
1. Genetic causes (Familial Hypercholesterolemia, Familial Combined Hyperlipidemia)
Secondary
- Obesity/Metabolic syndrome
- Diet
- Alcohol -elevated TGs
- Diabetes Mellitus
- Hypothyroidsim
- Chronic liver disease
- Monoclonal gammopathy
- Drug induced
DDX Thrombocytopenia
- Pseudothrombocytopenia
a. Platelets clumped in vial due to inadequate coagulation; repeat in Na citrate/heparin
b. Dilutional-massive RBC transfusion without PLT replenishment; pregnancy. - Decreased production:
a. Aplasia -aplastic anemia
b. Infiltration -carcinoma, lymphoma, leukemia, fibrosis
c. Toxins-drugs (gold, EtOH, TMP-SMX)
d. Infection (rubella, HIV)
e. Ineffective megakaryopoesis -Bl2/folate deficiency, myelodysplasia, EtOH - Increased destruction:
a. Immune -autoantibodies (ITP, SLE, some lymphomas), drug antibodies (quinidine, heparin, penicillin), infections (EBV, malaria, gram negative septicemia, HIV), suspected drug antibodies (thiazides, ASA, phenytoin), post-transfusion
b. Nonimmune -DIC, pre-eclampsia, vasculitis, TTPIHUS
c. Sequestration -Hypersplenism [Splenomegaly alone may dccrease pIt to 40 000 max. If lower, look for concomitant defects in production/destruction (lymphoma, autoimmune dz)]
DDX Meningitis
Meningeal Disorders
• Other infectious meningitides -CSF makes dx
o Aseptic (viral) -enteroviruses, mumps, CMV, HSV II, adenovirus, HIV
o Syphillis
o Fungal
o TB
• Meningeal neoplasm-neoplastic cells in CSF
• SAH
Parenchymal Disorders • Viral encephalitis o Often co-exists with viral meningitis o Etiologies-arboviruses (mosquitoes), HSV I, HZV, EBV, rabies • Brain abscess • Cerebral toxoplasmosis • Bacterial endocarditis • Toxic/metabolic encephalopathies • Lyme Disease • Post-infectious encephalomyelitis
DDX Acute renal failure
Prerenal
- Absolute decrease in effective blood volume
a. Hemorrhage
b. Bums
c. Gl loss/Diarrhea - Relative decrease in blood volume
a. CHF (low cardiac output)
b. Sepsis
c. Liver failure/ Cirrhosis
d. Third spacing - Disordered autoregulation
a. Meds: NSAIDs, ACEls/ARBs, Calcineurin inhibitors (cyclosporine, tacrolimus)
b. Hypercalcemia
Renal
- Vascular
a. Vasculitis (Post -infectious, Wegener’s, PAN, HSP, etc.)
b. Malignant HTN
c. Thrombotic microangiopathy
d. Cholesterol emboli
e. Large vessel disease - Glomerular
a. Acute glomerulonephritis (Post-infectious, Anti-basement membrane) - Tubular
a. Acute tubular necrosis (Ischemic vs Nephrotoxic)
b. Exogenous: Aminoglycosides, Amphotericin B, Dyes, NSAIDs, ACEIs
c. Endogenous: Hemoglobinuria, fuyoglobinuria, myeloma, uric acid, oxalate
Postrenal (especially if solitary kidney)
- Neurogenic
- Anatomic
a. Ureter -Stones, Strictures
b. Bladder -Prostatic hypertrophy, Bladder CA
c. Urethra
** 70 -75% of cases are due to Prerenal and ATN
Precipitants/causes of DKA (7)
- Infection
- Infarction (stroke, MI)
- Ischemia
- Intra-abdominal (appendicitis, cholecystitis, peritonitis, pancreatitis)
- Iatrogenic (steroids, insulin dose)
- Incision
- Intoxication (ETOH, or other drugs)
- Initial presentation
- Insulin - Non compliance
DDX urethral discharge men (4)
- Neisseria Gonorrhea
- Chlamydia
- Non gonococcal urethritis (Chlaymydia)
- Syphilis
Causes of Urinary retention
Anatomic
1. Prostate: BPH, prostatitis, prostate Ca
2. Urethra: stricture/scarring, trauma
3. Other: Cystocele, fecal impaction, stone
Neurologic
4. Hypotonic bladder – DM, sacral cord lesions, spinal shock, disc herniation
5. Detrusor sphincter dysynergy – MS, suprasacral spinal cord lesions
6. Cauda Equina
Medications
7. Anticholinergic
8. Psychtopics
9. Narcotics
Infection
10. Infection: UTI can present as retention and overflow incontinence in elderly
Causes of Hematuria (10)
Hint: approach most common then Anatomic
Tumor, infection, Trauma, Stones
Peds: think GN and congenital anomalies
Pseudohematuria
- Dyes (beets, juices)
- Hemoglobin
- Myoglobin
- Drugs (Rifampin)
- Porphyria
- Menses
Pre-renal
7. Bleeding d/o, Anticoagulants, Sickle cell,
Tumor, infection, Trauma, Stones (Renal, ureter, bladder, urethra)
Renal 1. Trauma 2. Stones 3. Carcinoma (RCC, TCC) 4. Wilms Tumor 5. Pyelonephritis 6. Glomerulonephritis 7. Intersitital Nephritis 8. Tuberculosis 9. PCOS 10. Arteriovenous malformation Ureter 11. Stone 12. Tumor Bladder 13. Cystitis 14. Tumor 15. Stones 16. Polyps Urethral 17. Urethritis 18. Stones 19. Tumors 20. Urethral stricture 21. Granuloma
DDX unconscious patient
Drugs
- ETOH
- Toxins
- Amphetamines, Opiods, cocaine, TCA, OD’s
- Withdrawals
Infection
- Meningitis
- Encephalitis
- Sepsis
Metabolic
- Electrolytes (K, Na, Ca)
- TSH – thyrotoxicosis
- Adrenal insuff
- Hypoglycemia
- Hypoxia
- Hypercarbia
- Uremia
Structural
- Seizure
- Trauma (EDH, SDH, SAH, diffuse axonal injury, bilat cortical injury)
- SAH (non-traumatic)
- ICH
- Mass/ Incr ICP
- MI
Name 10 things that are dangerous causes of HA that dont show on CT
- CO poisoning
- Temporal arteritis
- Acute angle closure
- Cerebral venous thrombosis
- Cerebellar stroke
- Early stroke
- Late >6hr SAH
- Sential HA prior to index SAH
- Meningitis
- Encephalitis
- Optic neuritis
Causes of Parkinsonism (6)
- Drug induced (antipsychotics, antiemetics)
- Toxins: CO, organic solvents
- Head trauma
- Tumor
- Any brain lesion affecting striatonigral circuits
- Metabolic: hypoparathyroid, wilsons
- Infectious: Syphilus, Toxoplasmisos, prion disease
DDX Back pain (10)
- Trauma
- Cauda equina
- Cord compression (tumor, mass)
- Cancer, MM
- Discitis
- Osteomyelitis
- Epidural abcess
- Spinal stenosis
- Sciatica
- Spondylarthropathies (ankylosing spondylitis, reactive arthritis, enteropathic spondylitis)
- Ao Dissection
- AAA
- Pyelonephritis, renal colic, pancreatitis
What toxic ingestion can be diaylzed?
ISTUMBLE Isopropanol and other BBs (AANTS) Salicyclates Theophylline Uremia Methanol Barbituates (phenobarbitol) Lithium Ethylene glycol
They have to have low protein binding, low molecular weight and water soluble (stays in blood) and low volume of distribution
DDx of hyperthermia?
DINEEO Drugs - cocaine - sympathemetics (amphetamines) - withdrawal sydromes - Neuroleptic malignant syndrome - Serotonin syndrome - Anticholinergic syndrome - Malignant hyperthermia
Infections
- Meningitis
- Encephalitis
- Abscess
- Sepsis
- Typhoid, Malaria
Neurological
- Hypothalamic stroke
- Status epilepticus
- Cerebral hemorrage
Environmental
- Heat, humidity
Endocrine
- Pheochromocytoma
- Thyroid storm
- DKA
Oncologic
- Lymphoma, Leukemia
Ddx Non-AG metabolic acidosis?
HARDUP
or GI loss vs. Renal loss
Hyperalimentation - TPN
Acetazolamide
Renal tubular acidosis (Type I = distal, Type II = proximal, Type IV = hyporeninemic hypoaldosteronism)
Diarrhea
Uretosignmoid fistula (colon will waste bicarbonate)
Pancreatic fistula (because of alkali loss - the pancreas secretes a bicarbonate rich fluid)
Ddx High AG metabolic acidosis?
MUDPILES Methanol Uremia DKA Paraldehyde/propylene glycol Infection, Iron, Isoniazid Lactate Ethylene glycol
Ddx High Osmolar Gap?
MAEDIE Methanol Acetone Ethanol Diuretics (mannitol, sorbitol) Isopropanol Ethylene glycol
Ddx VT (4)
- ACS
- Scarring (old infarct)
- Electrolytes (K, Ca, Mg)
- Hypoxia
DDx of Sick neonate (9)
Sepsis, Sepsis, Sepsis
T-Trauma (nonaccidental and accidental)
H-Heart disease/hypovolemia/hypoxia E-Endocrine (congenital adrenal hyperplasia, thyrotoxicosis)
M-Metabolic (electrolyte imbalance)
I-Inborn errors of metabolism: Metabolic emergencies
S-Sepsis (meningitis, pneumonia, urinary tract infection)
F-Formula mishaps (under- or overdilution) I-Intestinal catastrophes (volvulus, malrotation, intussusception, necrotizing enterocolitis) T-Toxins/poisons
S-Seizures
Causes of Afib (10)
- PE
- Ischemia
- Resp Dz - COPD
- Atrial enlargement
- TSH
- ETOH
- Sepsis
- HTN Cardiomyopathy
- Valvular dz
- CHF
- SSS
- Myocardial contusion
- Cardiac surgery
- Catecholamine excess
- Accessory pathway - WPW
Ddx Microcytic anemia (5)
- Fe Def anemia
- Thalassemia
- Anemia of Chronic dz
- Lead poisoning
- Sideroblastic anemia