DDS LAB_ QUIZ 1 Flashcards
LIQUID DOSAGE FORMS
- STERILE SOLUTIONS
- NON-STERILE SOLUTIONS
- SOLUTIONS
inserted directly to the body
STERILE SOLUTIONS
Example of Sterile Solutions
irrigation, nasal, optic, parenteral, ophthalmic
Example of non-sterile solutions
Mouthwash, Elixirs, Tinctures, Fluid extracts
Usually dissolved in water
Solutions
homogeneous solution
Solutions
Uniformity of doses
Solutions
Advantages of solutions:
- Easier to swallow (children, geriatrics, & unconscious)
- More quickly effective
- homogeneous
- dilute irritant actions
Disadvantages of solutions:
- Bulky for transport
- difficult to mask taste & odor
- needs an accurate spoon to administer drug
indicates the maximum concentration to which a solution may be prepared with that solvent
SOLVENT
concentrated solution
Saturated solution
No more solute can be dissolved
Saturated solution
Diluted solution
Unsaturated solution
More solute that can be dissolve
Unsaturated/Diluted solution
dissolving the solute
simple solution
reacting 2 or more solutes
solution by chemical reaction
like dissolves like
solution by extraction
a number of medicinal agents and provided in a dry powder or granule form
dry mixture
for reconstitution with a prescribe amount of water
dry mixture
mostly antimicrobials
reconstitution
solute is surrounded by solvent particles
solvation
very soluble
<1
freely soluble
1-10
soluble
10-30
sparingly soluble
30-100
slightly soluble
100-1000
very slightly soluble
1000-10000
practically insoluble
> 10000
Normal saline solution
0.9% or 0.9g NaCl in 100ml of water
important factor in determining the solubility of a drug and in preparing its solution
temperature
heating can facilitate solubility
Temperature
weak acids or weak bases
pH of the solvent
ex: alkaloids
weak bases
ex: barbiturate drugs
weak acids
weak base + strong acid
salt (soluble)
weak acids + strong base
soluble salts
4th major factors affecting solubility
various chemicals and other properties of both solute and solvent
5th major factor affecting solubility
pressure
6th major factors affecting solubility
particle size
7th major factor affecting solubility
physical agitation
2nd major factor affecting solubility
temperature
1st major factor affecting solubility
solvent
3rd major factor affecting solubility
pH of the solvent
factors to consider in making solutions
- solution pH
- buffers
- isotonicity
- viscosity
- preservatives
Preservatives
- Effective against a spectrum of wide organisms.
- Stable
- Non-toxic; non-sensitizing
- Compatible w/ other ingredients
- Free of taste and odor
Types of preservatives
- Acidic
- Neutral
- Mercurials
- Quarternary Ammonium Compounds
Benzoic acid
What type of preservative?
Acidic
used to inhibit oxidation
Antioxidants
EDTA
ethylenediamine tetraacetic acid
- sucrose
- polyhydric alcohols
Sweetening agents
natural and parenteral resources
flavors & perfumes
Oral solutions
Internal Solutions
Parenteral Solutions
Internal Solutions
Vaginal, Rectal, Oral, Nasal, Topical
External Solutions
Solutions by simple solution
- Calcium Hydroxide Solution USP
Calcium Hydroxide Solution USP
Lime hydrate/ caustic lime/ limewater
protects against extraneous solids
Well-closed container
protects from extraneous solids, liquids, or vapors
Tight container
impervious to air or any gases
Hermetic container
protects the contents from photochemical deterioration
Light resistant containers
Astringent
Toner
External
- Astringent
- Topical Protective
Internal
- Antacid
- Calcium Supplement
Strong Iodine Solution
Lungol’s Solution
Thyroid crisis (storm)
Thyrotoxis
a condition in which thyroid gland makes too much thyroid hormone
Hyperthyroidism
Freezer
not exceeding 8 *c
refrigerator
not exceeding 8*c
cool
8c - 15c
room temperature
20c - 25c
controlled room temperature
0c - 15c
warm
30c - 40c
excessive heat
40*c and above
Mild ticture/ weal solution of iodine
Iodine Tincture
alcoholic or hydroalcoholic solution
Iodine tincture
contains active principles of crude drugs
iodine tincture
Betadine
Povidone Iodine Solution
Anticoagulant Sodium Citrate Solution USP
parental products