Dbchbceh

Question 1

What type of receptor is GABA-A

Answer 1

Ion channel

Question 2

Name 3 positive allosteric modulators of the gaba A receptor

Answer 2

Ethanol, BDZ, barbiturates

Question 3

What type of receptor is GABA B

Answer 3

GPCR

Question 4

What is baclofen used for?

Answer 4

GABA B modulator … used for muscle spasms

Pump inserted under skin

Question 5

GHB is more commonly known as?

What receptor does it bind to

Answer 5

Date rape drug

Causes sedation, unconsciousness, etc

Question 6

What is the result of an antagonist of inhibitor receptors like GABA?

Answer 6

Inhibition of inhibitory receptors = excitation

• hyperactivity
• violent muscle spasms

Question 7

Which serotonin receptor is an ion channel?

Answer 7

5-HT3

Question 8

Describe current theory of depression

Answer 8

Cortisol and glutamate are increase = excitotoxicity

NA and 5-HT are decreases

Question 9

Name the enzymes that break down MAO

Answer 9

MAO-A and COMT

Question 10

describe MOA of TCAs

Answer 10

Inhibit the reuptake of noradrenaline and serotonin

Question 11

What off target receptors do TCA bind to

Answer 11

Histamine
A-adrenoreceptors
Muscarinic antagonists

Question 12

What is a potential fatal side effect of TCAs and the related receptor

Answer 12

Tachycardia - due to muscarinic receptors