CNS Flashcards
What is glutamate
Excitatory neurotransmitter in CNS
Describe the conversion of glutamine into glutamate
Glutamine is converted to glutamate presynaptically.
GLU then packaged into a vescicle and removed via exocytosis when an action potential arrives.
Then gets converted back to glutamine after binding to astrocyte
NMDA is a receptor for which neurotransmitter
Glutamate
What effect does glycine have on NMDA receptor?
It is a positive allosteric modulator. It increases the receptor’s affinity for glutamate
Ketamine and PCP are non-competitive antagonists of which receptor?
NMDA
What effect do ketamine and PCP have on the receptor?
They bind intracellularly and block ion movement through the channel
GABA is the primary — neurotransmitter in the CNS
Inhibitory
What are the 3 monoamine neurotransmitters
Dopamine, serotonin and noradrenaline
Current theory for the cause of depression is…
Reduced activity of NA and 5-HT
Goal of depression pharmacology is… and …
Prevent neurotransmitter reputable by the neuron, and to prevent enzymatic breakdown
Compare TCAs and SNRIs
Both inhibit reuptake of 5-HT and NA, but SNRIs are more specific with less off-target binding
SSRI has 2 mechanisms of action. Describe them
- slow reuptake
- slow degradation
Monoamine oxidase inhibitors bind to which receptor?
MAO-A
List positive symptoms of schizophrenia
Hallucinations, delusions, hyperactivity
List negative symptoms of schizophrenia
Withdrawn and flat mood
