Day 7 Obstetrics Flashcards
A 23-year-old primigravida woman at 36 weeks gestation presents with mild irregular labor pains in the lower abdomen.
On examination she has a firm, posterior, closed cervix.
Fetal heart tones are heard. The pain stops during the consultation.
What is the most appropriate next step?
Reassure and discharge
False Labor
Occurs in the last 4 weeks of pregnancy
Presentation:
- contractions felt in the lower abdomen.
- The contractions are irregular and occur every 20 minutes.
- Progressive cervical changes are absent.
False labour features
(4)
False Labor
Occurs in the last 4 weeks of pregnancy
Presentation:
contractions felt in the lower abdomen.
The contractions are irregular and occur every 20 minutes.
Progressive cervical changes are absent.
What are the stages of labour?
stage 1:
stage 2:
stage 3:
Labour may be divided in to three stages
stage 1: from the onset of true labour to when the cervix is fully dilated
stage 2: from full dilation to delivery of the fetus
stage 3: from delivery of fetus to when the placenta and membranes have been completely delivered
A 22-year-old woman has just had an artificial rupture of membranes in order to augment a slowly progressing labour.
Her partner is helping her move into a more comfortable position when she suddenly becomes breathless and collapses from the bed.
She is unconscious and unresponsive with a blood pressure of 82/50 mmHg and a heart rate of 134 beats per minute.
What is the most likely diagnosis?
A history of sudden collapse occurring soon after a rupture of membranes is suggestive of amniotic fluid embolism.
The patient is clearly too unwell for this to be a simple vasovagal event.
Amniotic fluid emboli can indirectly lead to myocardial infarcts, but It is hard to arrive at a primary diagnosis of myocardial infarction without mention of preceding chest pain.
Occult bleeding and hypovolaemic shock would also typically evolve at a slower pace.
Postural orthostatic tachycardia syndrome is more common in women of a reproductive age but would not be associated with marked hypotension as present here.
A 34-year-old woman attends the antenatal clinic at 37 + 4 weeks.
She is concerned as her other child developed an infection 2 days after being born.
The doctor offers her intrapartum antibiotics to reduce the risk of this happening again.
She has no known drug allergies.
What antibiotic should she be given prophylactically intrapartum?
Benzylpenicillin is the antibiotic of choice for Group B Strep prophylaxis
IV benzylpenicillin is the correct answer. When a woman has previously had a baby with early or late GBS disease, they should be offered intrapartum prophylaxis in subsequent pregnancies.
75% of cases of early-onset sepsis in the UK are caused by GBS, so the assumption can be made that her older child had GBS sepsis.
Risk factors for cord prolapse include:
(6)
Risk factors for cord prolapse include:
- prematurity
- multiparity
- polyhydramnios
- twin pregnancy
- cephalopelvic disproportion
- abnormal presentations e.g. Breech, transverse lie
Around 50% of cord prolapses occur when? (1)
How is the diagnosis of cord prolapse made? (2)
Around 50% of cord prolapses occur at artificial rupture of the membranes
The diagnosis is usually made when the
- fetal heart rate becomes abnormal and the cord is palpable vaginally
- the cord is visible beyond the level of the introitus
Management of cord prolapse
(5)
- the presenting part of the fetus may be pushed back into the uterus to avoid compression
- if the cord is past the level of the introitus, there should be minimal handling and it should be kept warm and moist to avoid vasospasm
- the patient is asked to go on ‘all fours’ until preparations for an immediate caesarian section have been carried out or the left lateral position is an alternative
- tocolytics may be used to reduce uterine contractions
- retrofilling the bladder with 500-700ml of saline may be helpful as it gently elevates the presenting part
* although caesarian section is the usual first-line method of delivery, an instrumental vaginal delivery is possible if the cervix is fully dilated and the head is low.*
A 31-year-old woman G3P1 at 28 weeks gestation attends maternity triage with bright red vaginal bleeding.
She reports not being in any pain.
On examination, her uterus is non-tender.
Cardiotocography (CTG) monitoring shows no evidence of uterine contractions or foetal compromise.
What is the most likely diagnosis?
Pain is usually absent in patients with placenta praevia
The clinical features described in this scenario are typical of placenta praevia: painless vaginal bleeding and a non-tender uterus.
Threatened miscarriage is incorrect, as this is defined as painless vaginal bleeding occurring before 24 weeks gestation. Bleeding occurring after 24 weeks of pregnancy is an antepartum haemorrhage.
placenta praevia features
painless vaginal bleeding and a non-tender uterus.
A 24-year-old female who is 10 weeks in to her first pregnancy presents for review. Her blood pressure today is 126/82 mmHg.
What normally happens to blood pressure during pregnancy?
Falls in first half of pregnancy before rising to pre-pregnancy levels before term
High risk groups of pre-eclampsia
(4)
- hypertensive disease during previous pregnancies
- chronic kidney disease
- autoimmune disorders such as SLE or antiphospholipid syndrome
- type 1 or 2 diabetes mellitus
Women who are at high risk of developing pre-eclampsia should take aspirin 75mg od from 12 weeks until the birth of the baby
Treatment plan for women who are at risk of developing preeclampsia
(3)
Women who are at high risk of developing pre-eclampsia should take aspirin 75mg od from 12 weeks until the birth of the baby
Hypertension in pregnancy in usually defined as (2)
Hypertension in pregnancy in usually defined as:
systolic > 140 mmHg or diastolic > 90 mmHg
or an increase above booking readings of > 30 mmHg systolic or > 15 mmHg diastolic
Describe Wood’s screw manoeuvre
Put your hand in the vagina and attempt to rotate the foetus 180 degrees
In this maneuver the anterior shoulder is pushed towards the baby’s chest, and the posterior shoulder is pushed towards the baby’s back, making the baby’s head somewhat face the mother’s rectum.
Key risk factors for shoulder dystocia
(4)
Key risk factors
fetal macrosomia (hence association with maternal diabetes mellitus)
high maternal body mass index
diabetes mellitus
prolonged labour
Management of shoulder dystocia
(2)
Senior help should be called as soon as shoulder dystocia is identified and McRoberts’ manoeuvre should be performed:
- this manoeuvre entails flexion and abduction of the maternal hips, bringing the mother’s thighs towards her abdomen
An episiotomy will not relieve the bony obstruction but is sometimes used to allow better access for internal manoeuvres.
Symphysiotomy and the Zavanelli manoeuvre can cause significant maternal morbidity and are not first-line options.
A 27-year-old woman who is 22-weeks pregnant presents to the emergency department after noticing a vesicular rash on her torso this morning. Upon further questioning you ascertain that her 4-year-old son developed chickenpox last week and the patient does not remember if she has had the condition before. She appears comfortable at rest.
You perform serological testing for varicella zoster virus which shows the following:
Varicella IgM = Positive
Varicella IgG = Negative
Which is the most appropriate management?
Chickenpox exposure in pregnancy > 20 weeks
if not immune give either oral antivirals or VZIG
A 32-year-old primigravida at 37 weeks attends the antenatal unit complaining of abdominal pain which is worse on the right side. She has also been vomiting. Her blood pressure is 148/97 mmHg. She denies any abnormal discharge and reports that fetal movements are still present. Her blood results are shown below.
Hb = 93 g/l
Platelets = 89 * 109/l
WBC = 9.0 * 109/l
Urate = 0.49 mmol/l
Bilirubin = 32 µmol/l
ALP = 203 u/l
ALT = 190 u/l
AST = 233 u/l
What is the most likely diagnosis?
HELLP syndrome (haemolysis, elevated liver enzymes and low platelets), a serious manifestation of pre-eclampsia.
Pre-eclampsia describes the emergence of high blood pressure during pregnancy that may be a precursor to a woman developing eclampsia and other complications.
It is classically a triad of 3 things:
1) new-onset blood pressure ≥ 140/90 mmHg after 20 weeks of pregnancy, AND 1 or more of the following:
2) proteinuria
3) other organ involvement (see list below for examples): e.g. renal insufficiency (creatinine ≥ 90 umol/L), liver, neurological, haematological, uteroplacental dysfunction
Potential complications of pre-eclampsia
(5)
Eclampsia
other neurological complications include altered mental status, blindness, stroke, clonus, severe headaches or persistent visual scotomata
Fetal complications
- intrauterine growth retardation
- prematurity
Liver involvement:
- (elevated transaminases)
Haemorrhage:
- placental abruption
- intra-abdominal
- intra-cerebral
Cardiac failure
Features of severe pre-eclampsia
(8)
Features of severe pre-eclampsia
- hypertension: typically > 160/110 mmHg and proteinuria as above
- proteinuria: dipstick ++/+++
- headache
- visual disturbance
- papilloedema
- RUQ/epigastric pain
- hyperreflexia
- platelet count < 100 * 106/l, abnormal liver enzymes or HELLP syndrome
High risk factors for preeclampsia (5)
Moderate risk factors for preeclampsia (6)
High risk factors
- hypertensive disease in a previous pregnancy
- chronic kidney disease
- autoimmune disease, such as systemic lupus erythematosus or antiphospholipid syndrome
- type 1 or type 2 diabetes
- chronic hypertension
Moderate risk factors
- first pregnancy
- age 40 years or older
- pregnancy interval of more than 10 years
- body mass index (BMI) of 35 kg/m² or more at first visit
- family history of pre-eclampsia
- multiple pregnancy
Pharmacological management of preeclampsia
(3)
Further management
- oral Labetalol is now first-line following the 2010 NICE guidelines.
- Nifedipine (e.g. if asthmatic) (calcium channel blocker)
- Hydralazine may also be used (vasodilator)
Delivery of the baby is the most important and definitive management step. The timing depends on the individual clinical scenario
A 26 year-old lady presents complaining of persistent itching. She has a history of eczema and uses emollients daily but this has not helped. She is currently 30 weeks pregnant. On examination there is evidence of excoriation on the hands but no obviously visible dermatitis.
Which of the following tests is the most important investigation to request and why?
(3)
Liver function tests
Pruritus is extremely common in pregnancy, affecting as many as a quarter of women.
Causes include exacerbations of eczema, polymorphic eruption of pregnancy, or simply just as the result of skin stretching and changes in circulation.
Pruritus in the absence of a rash should raise the possibility of obstetric cholestasis.
This potentially serious condition increases the risk of complications such as prematurity, passage of meconium, post partum haemorrhage, and possibly stillbirth.
Liver function tests and bile acids are therefore the most important tests to check.
Iron deficiency anaemia can also cause pruritus so full blood count would also be relevant.
Intrahepatic cholestasis of pregnancy features:
(3)
pruritus, often in the palms and soles
no rash (although skin changes may be seen due to scratching)
raised bilirubin
Intrahepatic cholestasis of pregnancy management:
(3)
Management
ursodeoxycholic acid is used for symptomatic relief
weekly liver function tests
women are typically induced at 37 weeks
When does acute fatty liver of pregnancy occur?
(2)
Acute fatty liver of pregnancy is rare complication which may occur in the third trimester or the period immediately following delivery.
Acute fatty liver of pregnancy features
(6)
Features
- abdominal pain
- nausea & vomiting
- headache
- jaundice
- hypoglycaemia
- severe disease may result in pre-eclampsia
Investigations for acute fatty liver of pregnancy
(2)
Investigations
- ALT is typically elevated e.g. 500 u/l
- HELLP syndrome
A 32-year-old woman presents to the antenatal clinic at 41-weeks gestation. She is concerned that she has not yet gone into labour.
She reports normal foetal movements and denies recent illness. This is her first pregnancy and there is no other past medical history of note.
On examination, her abdomen is soft with a palpable uterus in keeping with a term pregnancy.
Her Bishop’s score is calculated as 5.
What is the most initial step in the management of this patient?
A membrane sweep is a useful adjunct, prior to formal induction of labour, that may be done in the antenatal clinic
A 28-year-old woman presents the Emergency Department at 35-weeks gestation with lower abdominal pain and vaginal bleeding. She is alert and responsive. Physical examination revealed a heart rate of 115 bpm, blood pressure of 90/60 mmHg and O2 saturation of 99%. On neurological exam, her pupils were dilated and her reflexes were brisk.
Hb = 115 g/l
Platelets = 250*109/l
WBC = 5*109/l
PT = 12 seconds
APTT = 30 seconds
Which of the underlying condition would most likely explain the findings on the physical exam?
The scenario described in this question is consistent with that of placental abruption.
Cocaine abuse, pre-eclampsia and HELLP syndrome are known causes of placental abruption, which typically presents with hyperreflexia.
Cocaine Maternal risks
- hypertension in pregnancy including pre-eclampsia
- placental abruption
Cocaine Fetal risk
- prematurity
- neonatal abstinence syndrome
A 22-year-old woman who is 14 weeks pregnant presents to her GP as she thinks she has been exposed to an infectious disease. Her friend’s daughter has a crusty rash and a fever.
She has no past medical history and when questioned, doesn’t know whether she has had chickenpox as a child.
What is the first action to perform?
What is the next step?
Chickenpox exposure in pregnancy - first step is to check antibodies
If a pregnant patient >20 weeks gestation is found to not be immune to varicella-zoster after antibody testing, they should be prescribed varicella-zoster immunoglobulin or they should be given oral acyclovir 7-14 days post-exposure.
Oral acyclovir vs Varicella-zoster immunoglobulin
indications
Varicella-zoster immunoglobulin is indicated if the patient is shown to not be immune on antibody testing if they can receive it within 10 days of exposure. It provides rapid protection but is short-lived.
Oral acyclovir is indicated if a pregnant patient >20 weeks gestation develops chickenpox. It can also be used in caution in a patient <20 weeks gestation.
Fetal varicella syndrome (FVS)
What is the relevant time frame of gestation? (2)
What are the features? (5)
Fetal varicella syndrome (FVS)
risk of FVS following maternal varicella exposure is around 1% if occurs before 20 weeks gestation
features of FVS include
- skin scarring
- eye defects (microphthalmia)
- limb hypoplasia
- microcephaly
- learning disabilities
A 23-year-old woman is reviewed in the labour suite following a worrying cardiotocography (CTG) tracing. This is her first pregnancy, she has been in active labour for 70 minutes, and is receiving a spinal epidural for pain relief and IV oxytocin.
The CTG shows the following:
Foetal heart rate = 90 bpm(110 - 160)
Variability = 12 bpm(5 - 25)
Decelerations = absent
Contractions = 6-7 per 10 minutes (3 - 4)
This has been the case for 11 minutes. The mother’s heart rate is 62 bpm.
What is the most appropriate immediate next step?
(3)
This CTG is worrying and represents foetal compromise.
Whilst accelerations/decelerations and variability are both considered normal, a foetal bradycardia of under 100 bpm is considered pathological.
The first step is to consider whether it is the mother’s heart rate being picked up by the CTG pads. However, since we are told her heart rate is 62 bpm, we know that the heart rate given must be from the foetus.
There are many causes of foetal bradycardia, but in this case, it is likely due to too many contractions which are not allowing the foetus adequate perfusion.
A foetal bradycardia of over 10 minutes is an obstetric emergency and warrants immediate caesarean section, also known as a category 1 caesarean section.
Examples indications for a category 1 caesarean section include:
- suspected uterine rupture
- major placental abruption
- cord prolapse
- fetal hypoxia
- persistent fetal bradycardia
Indications for caesarian section
(11)
- cephalopelvic disproportion ABSOLUTE
- placenta praevia grades 3/4 ABSOLUTE
- pre-eclampsia
- post-maturity
- IUGR
- fetal distress in labour/prolapsed cord
- failure of labour to progress
- malpresentations: brow
- placental abruption: only if fetal distress; if dead deliver vaginally
- vaginal infection e.g. active herpes
- cervical cancer (disseminates cancer cells)
Categories of C-section
(4)
Caesarean sections may be categorised by the urgency
Category 1
- an immediate threat to the life of the mother or baby
- examples indications include: suspected uterine rupture, major placental abruption, cord prolapse, fetal hypoxia or persistent fetal bradycardia
- delivery of the baby should occur within 30 minutes of making the decision
Category 2
- maternal or fetal compromise which is not immediately life-threatening
- delivery of the baby should occur within 75 minutes of making the decision
Category 3
- delivery is required, but mother and baby are stable
Category 4
- elective caesarean
A 26-year-old primary school teacher has come to see you 4 days after contact with a child who had a vesicular rash on his head and trunk. She is currently 16 weeks pregnant and apart from some morning sickness, has felt completely well in herself. Blood tests reveal she is non immune to varicella zoster virus.
What would be the next step in your management plan?
A single dose of varicella-zoster immunoglobulin (VZI)
If the pregnant woman is not immune to varicella zoster virus and she has had a significant exposure, she should be offered varicella-zoster immunoglobulin (VZIG) as soon as possible. VZIG is effective when given up to 10 days after contact (in the case of continuous exposures, this is defined as 10 days from the appearance of the rash in the index case).
Tina is a 30-year-old woman who has recently given birth to a baby girl 6 weeks ago. At the 6 week check, you can see from her records that she has previously been on citalopram for moderate depression, however, this was stopped before her pregnancy. She tells you that she is finding it difficult to cope and is feeling extremely low. On examination, she is tearful and has a flat affect. She denies any thoughts to harm herself or her baby but is keen to try a medication that would be safe to use with breastfeeding.
Which of the following medications may be appropriate for her to start?
Sertraline or paroxetine are the SSRIs of choice in breastfeeding women