Day 6 - 29/09/14

Question 0

What is the compliment system?

Answer 0

A BIOCHEMICAL CASCADE that occurs in all vertebrates that clears pathogens.

Question 1

What is innate immunity?

Answer 1

Innate immunity is NON-SPECIFIC immunity and is the FIRST LINE OF DEFENCE.

Question 2

How does the complimentary system work?

Answer 2

• INACTIVE plasma PROTEINS are ACTIVATED at bacterial SURFACE
• The PROTEINS INITIATE a sequential ENZYME CASCADE
• Enzymes LYSE pathogen cell membranes.
• Enzymes regulate inflammation by
  - chemotaxis (movement in response to chemicals)
  - microbial opsonisation (marked for ingestion by phagocytes)

Question 3

What does a deficiency in the complimentary system result in?

Answer 3

Recurrent infections.

Question 4

Name some pathogen associated molecular patterns (PAMPS) and there corresponding pattern recognising receptors.

Answer 4

Bacterial lipoprotein - TLR1
Peptidoglycan - TLR2
dsRNA - TLR3
LPS - TLR4

Question 5

How does adaptive immunity work with innate immunity?

Answer 5

The antibodies created by lymphocytes (adaptive immunity)
Enhance the effectiveness of the 
-complement cells
-phagocytes
(Innate immunity)

Question 6

Define symptoms of inflammation.

Answer 6

Local Redness, heat, pain, swelling

Question 7

Define Inflammation.

Answer 7

An example of immune response in action to injury.

Question 8

What are the two types of inflammation?

Answer 8

Chronic inflammation

Acute inflammation

Question 9

What causes chronic inflammation?

Answer 9

Persistence of causative agent

eg. Inert particles/ self tissue in auto immunity

Question 10

What causes acute inflammation?

Answer 10

Infection or Injury.