day 3: transport Flashcards
Transporters can be channel or carrier? What are some differences between the two
channel- accessed from either side simultaneously, very rapid, selectivity filter, gated
carrier- transition between conformation due to thermal energy, very slow
how are the graphs of carrier mediated solute flux different from simple diffusion
hyperbolic vs linear
How do P-class ATPases work?
the phosphorylation/dephosphorylation by ATP caused conformational changes that affect the affinity to solute based on facing in/out. It is active transport
what are the three primary active transporters (P-class ATPases)
Na+-K+
Ca2+
H+
What are ABC transporters
a family of a variety of transporters which have 2 nucleotide binding domains and 2 transport domains and 6 transmembrane regions
what are two examples of ABC transporters and how are they different?
MDR (multidrug resistant)- removes drugs from cells and is directly ATP dependent
CFTR- transport of Cl- and is indirectly ATP dependent
the na+k+ Atpase is found where?
in plasma membrane of all animal cells
the ca2+ atpase is found where
the plasma membrane and endoplasmic reticulum membrane
what is the direction of the na+k+ atpase?
3 Na+ out of the cell and 2K+ into the cell for every ATP
what is the direction and quantity of transport in the Ca2+ atpase
1 Ca2+ in (PM)
2 Ca2+ in (ER)
for H+ ion out for every Atp
what is coupled transport? It is considered what kind of transport?
the use of the downhill movement of one solute to assist in the uphill movement of another
secondary active transport
what are two examples of cotransport in coupled transport?
Na+/glucose
Na+Cl-k+
what are two examples of exchange transport in coupled transport?
Na+/Ca2+
Na+/H+
High osmolarity of a solution means ___ water concentration in that solution, therefore water moves from ___ osmolarity to ____ osmolarity
LOW
LOW to HIGH
what does “pi” stand for?
it is the osmotic pressure of a solution. It is how much pressure is required to balance the osmotic force of the solution
