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Pathology Fast Review (self-reviewer) > Day 3 Patho Fast Review > Flashcards

Day 3 Patho Fast Review Flashcards

1
Q

Stained using Sudan IV and Oil-Red-O?

A

Steatosis (Fatty Change)

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2
Q

Biochemical Disorder in Heme synthesis presents with skin blisters due to photosensitivty?

A

Porphyria

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3
Q

Most common variant of Porphyria? What enzyme is deficient?

A

Porphyria cutanea tarda due to deficent URO decarboxylase

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4
Q

Which DMARD drugs may cause reactivation of latent TB?

A

Infliximab

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5
Q

Only protein that undergoes final modification in the RER (not in Golgi Apparatus)?

A

Collagen

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6
Q

Amplifies Platelet Aggregation leading to primary Hemostasis?

A

Thromboxane A2 (TXA2)

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7
Q

Glycoprotein Iib-IIIa inhibitors?

A

Abciximab, eptifibatide, tirofiband and Glanzmann’s Thrombasthenia

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8
Q

Lines of Zahn (laminations)?

A

Antemortem Thrombosis

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9
Q

Libmanns Sacks Endocarditis occurs in?

A

SLE

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10
Q

Most common casuse of native valve Endocarditis

A

viridans Streptococci

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11
Q

Most common cause of Prosthetic valve endocarditis?

A

Staph. Epidermidis

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12
Q

Which bacterium implicated in marantic endocarditis?

A

Streptococcus bovis

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13
Q

most common ECG manifestation of Pulmo Embo?

A

Sinus Tachycardia

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14
Q

Gold standary diagnosis of pulmo embo?

A

Pulmonary Angiography

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15
Q

DVT that presents as a pale, painfule leg with a diminished arterial pulse due to vasospasm>

A

Phlegmasia alba dolens

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16
Q

DVT that presents as a cyanotic, painful leg due to extensive thrombotic occlusion?

A

Phlegmasia cerulea doles

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17
Q

Most severe form of Meningococcemia

A

Waterhouse-friderichsen syndrome (due to bilateral adrenal hemorrhage leading to adrenal insufficiency)

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18
Q

Mutation in the gene encoding LDL receptor?

A

Familia Hypercholesterolemia

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19
Q

Hexosaminadase alpha-subunit deficiency?

A

Tay-Sach Disease (GM2 Gangliosidosis)

20
Q

Predominant CNS and retinal involvement, Cherry Red Spot in the Macula?

A

Tay-Sach Disease (GM2 Gangliosidosis)

21
Q

Zebra bodies, massive splenomegaly and hepatomegaly, cherry red spot in the macula?

A

Niemann-Pick Disease

22
Q

Most common lysosomal storage disordr? Mutations in the Glucocerebrosidase?

A

Gaucher Disease

23
Q

(Mucopolysaccharidoses) Alpha-L-iduronidase defect (with corneal clouding, musculoskeletal abnormalities, CNS and CV problems)

A

Type 1 Hurler

24
Q

(Mucopolysaccharidoses) Iduronososulfate sulfatase with Musculoskeletal and CNS manifestations

A

Type 2 Hunter

25
Q

(Mucopolysaccharidoses) N-acetylgalactosamine 6-sulfatase deficiency with Corneal clouding, MS and CV manifestations

A

Type IV Morquio

26
Q

Balloon Cells (distended cells with apparent clearing of the cytoplasm); (+) Zebra bodies?

A

Mucopolysaccharidoses

27
Q

(Glycogen Storage Disease) Glucose-6-phosphatase deficiency; Severe hypoglycemia

A

Type 1 von Gierke

28
Q

(Glycogen Storage Disease) alpha-1,4-glucosidase def; with cardiomegalym muscle weaknessm death by 2 years

A

Type 2 Pompe

29
Q

(Glycogen Storage Disease) Glycogen Debranching Enzyme; mild hypoglycemia; liver enlargement

A

Type 3 Cori

30
Q

(Glycogen Storage Disease) Muscle glycogen phosphorylase; muscle craps and weakness on exercise

A

Type V McArdle

31
Q

First human inborn error of metabolism; black urin; Lack of Homogentistic Oxidase?

A

Alkaptonuria

32
Q

Most commonly associated with Rockerbottom feet? Edwards or Patau?

A

Patau

33
Q

Polydactyly, Cleft palate, holoprosencephaly?

A

Patau (Trisomy 13)

34
Q

Chrom 22q11.2 Deletion?

A

DiGeorge Syndrome

35
Q

CATCH 22 (Cardiac Defects, Abnormal Facies, Thymic Aplasia, Cleft Palate, Hypocalcemia, 22 q11.2 deletion)

A

DiGeorge

36
Q

lack of NADPH oxidase activity? Failure of oxidative burst?

A

Chronic Granulomatous Disease

37
Q

AR; failure of phagolysosomal fuion

A

Chediak-higashi Syndrome

38
Q

PSA Marker?

A

Prostate CA (may be eleveated in BPH and Prostatitis)

39
Q

Prostatic acid Phosphatase

A

Prostate CA

40
Q

CEA marker?

A

Colorectal and Pancreatic CA, Gastic CA and Breast CA

41
Q

AFP Marker?

A

Hepatocellular CA, Non-seminomatous GCS (yolk sac tumor)

42
Q

b-HCG

A

Hydatidiform more, choriocarcinoma, gestational trophoblastic tumor

43
Q

S-100

A

Melanoma, neural tumors, astrocytomas

44
Q

Alkaline Phosphatase

A

Mets to bone, obst. Biliary diseae, paget’s disease of bone

45
Q

Bombesin marker?

A

Neuroblastoma, lung and gastric CA

46
Q

TRAO marker?

A

Hairy Cell Leukemia (B-cell neoplasm)

47
Q

CA 19-9 marker?

A

Pancreatic Adenocarcinoma

Pathology Fast Review (self-reviewer) (4 decks)

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