Davis 1991 Flashcards
What did Davis argue?
That serotonin and dopamine cause sz. Expanded on Rossums 1966 study.
What does excess dopamine receptors in the meso-limbic pathway lead to?
Positive symptoms. (Associated).
What does a lack of dopamine receptors in the meso-cortical pathway mean?
Negative symptoms. (Associated).
Where did Davis collect his data from?
- Post-mortem studies.
- Metabolite studies.
- Brain imaging data.
- Animal studies.
What is clozapine?
A drug which block both dopamine and serotonin receptors. It is effective in reducing both positive and negative symptoms.
What’s serotonins link to dopamine?
Serotonin regulates dopamine in areas such as the meso-limbic pathways.
What did Davis hypothesise that sz is caused by?
- Hypodopaminergia in the frontal lobes.
* Hyperdopaminergia in the striatum.
What are negative symptoms a result of?
Hypodopaminergia in the frontal lobes and mean-cortical pathways.
What are positive symptoms a result of?
Hyperdopaminergia in the striatum and the meso-limbic pathway.
