D - Glaucoma Histopath 2 - Week 2 Flashcards

1
Q

How does lens cell death differ in angle-closure glaucoma compared to open angle? Explain why this occurs and how it presents visually

A

Angle closure results in an acute rise to very high IOP levels. This leads to necrosis of the lens epithelium, which appears as “Glaukomflecken” (grey-white lens epithelial and anterior cortical lens opacities; beneath anterior lens capsule)

(cf open angle, which is apoptosis)

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2
Q

What percentage of aqueous drains through the uveoscleral route? What about via trabecular meshwork?

A

Uveoscleral: 85-95%
Trabecular: 5-15%

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3
Q

What feature of the trabecular meshwork allows for fine control of aqueous outflow?

A

giant vacuoles on the endothelial surface of schlem’s canal

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4
Q

What is the role of trabecular cells (2) and where are they found?

A

In the cribriform region of the trabecular meshwork, there are trabecular cells that:
- Produce a gel to fill in holes + stick to debris
- phagocytose debris to clean TM

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5
Q

List 2 trabecular mechanisms for angle compromise

A

Congenital/juvenile (formation problems)
Mechanical blockage (e.g. pigment, debris, vacuole dysfunction)

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6
Q

What does posterior trabecular dysfunction lead to? (2)

A

Reduced venous drainage
Increased venous backpressure

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7
Q

List 2 anatomical causes for angle closure

A

Anterior membrane overgrowth (Irido Corneal Endothelial “ICE” syndrome)
Occlusion of PTM by iris (iris “push” or “pull”)

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8
Q

continue later

A

yeah

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