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Molecular Biology Flashcards > Cytoskeleton > Flashcards

Cytoskeleton Flashcards

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1
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Learning Outcomes

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  • Be able to list three types of cytoskeleton
  • Understand the role of each cytoskeleton
  • Describe their dynamic reorganisation
  • Identify the role of accessary proteins
    * Alberts et al. Molecular Biology of the Cell, Ch16
  • Alberts et al. Essential Cell Biology, Ch17
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2
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Reading:

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3
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3
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3 major protein filaments that form the cytoskeleton

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Actin filaments
- Determining the shape of cell’s surface
- Necessary for whole-cell locomotion
- Driving the pinching of one cell into two (L33)
Microtubule
- Determining the positions of membraneenclosed organelles
- Directing intracellular transport
- Forming the mitotic spindle during cell division
(L33)
Intermediate filaments
- Providing mechanical strength

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4
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4
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3 major protein filaments that form the cytoskeleton

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5
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Actin Filaments

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5
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Dynamic arrangement of cytoskeleton

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6
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Accessary proteins of
the actin cytoskeleton

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7
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Accessary Proteins of Actin Filaments

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8
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Actin arrays in a cell

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9
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Myosin II

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10
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Actin sliding by Myosin

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11
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Ca2+ dependent skeletal muscle contraction

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12
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Myosin superfamily

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13
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14
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Microtubules

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15
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Dynamic Instability of Microtubules

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16
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Microtubules grow from centrosome

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17
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Accessary proteins
for microtubule
cytoskeleton

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18
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Motor proteins on microtubule

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19
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Organelle transportation

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19
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Intermediate filaments

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19
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Motile cilia and flagella

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20
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Intermediate filaments

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21
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Nuclear lamina - Lamin

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22
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Cells change their morphology based on how they feel

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23
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Summary

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Actin filaments
- Treadmilling
- Actin-myosin for muscle contraction
- Accessary proteins
Microtubule
- Dynamic instability
- Different arrangements of tubulin for microtubule, centriole, and cilia
- Motor proteins; Kinesin + and Dynein -
Intermediate filaments
- Providing mechanical strength
- e.g. Nuclear Lamina

Molecular Biology Flashcards (20 decks)

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