Cytoskeleton Flashcards
Learning Outcomes
- Be able to list three types of cytoskeleton
- Understand the role of each cytoskeleton
- Describe their dynamic reorganisation
- Identify the role of accessary proteins
* Alberts et al. Molecular Biology of the Cell, Ch16 - Alberts et al. Essential Cell Biology, Ch17
Reading:
3 major protein filaments that form the cytoskeleton
Actin filaments
- Determining the shape of cell’s surface
- Necessary for whole-cell locomotion
- Driving the pinching of one cell into two (L33)
Microtubule
- Determining the positions of membraneenclosed organelles
- Directing intracellular transport
- Forming the mitotic spindle during cell division
(L33)
Intermediate filaments
- Providing mechanical strength
3 major protein filaments that form the cytoskeleton
Actin Filaments
Dynamic arrangement of cytoskeleton
Accessary proteins of
the actin cytoskeleton
Accessary Proteins of Actin Filaments
Actin arrays in a cell
Myosin II
Actin sliding by Myosin
Ca2+ dependent skeletal muscle contraction
Myosin superfamily
Microtubules
Dynamic Instability of Microtubules
Microtubules grow from centrosome
Accessary proteins
for microtubule
cytoskeleton
Motor proteins on microtubule
Organelle transportation
Intermediate filaments
Motile cilia and flagella
Intermediate filaments
Nuclear lamina - Lamin
Cells change their morphology based on how they feel
Summary
Actin filaments
- Treadmilling
- Actin-myosin for muscle contraction
- Accessary proteins
Microtubule
- Dynamic instability
- Different arrangements of tubulin for microtubule, centriole, and cilia
- Motor proteins; Kinesin + and Dynein -
Intermediate filaments
- Providing mechanical strength
- e.g. Nuclear Lamina
