Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Modul2-week3 > Cytoskeleton > Flashcards

Cytoskeleton Flashcards

1
Q

Microflament:MOST FLEXIBLE /stress fiber

A

Protein subunit:actin
Pattern: Fibrillary(F actin) and globular(G actin)
Isoform: alpha,beta,gamma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

From g actin molecule to f actin filament

A

G actin sentezlenir hücrede
ATp ile bağlanarak G-actin Pool oluşturur
F -actin oluşur bunun iki ucu var:
+end:polymerization and depolymerization
-end:capped by actin bindin protein to stop alongation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Actin:most abundant protein in intracellular matrix

A

Collagen:most abundant protein in extracellular matrix

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

F actin polymerization/microfilament

A

Nucleation: g actin moleküle atp bağlanması ve adp oluşumu elongationı başlatır
Elongation:g actin moleküller hücrenin ortasında bir araya gelir
Steady statue:polymerization ve depolymerization hızları aynı

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Mikrofilament nerede bulunur

A

Epitel doku
Microvillus
Brush border
Diapedesis: nötrofilde esneklik kazandırır/spektrin proteini
Myosin==kas hücrelerinde

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Actin drug

A

Cytocholasin=polimerizasyonu uyarır mushroom
Phalloidin=depolimerizasyonu engeller mushroom
Latrunculin=sponges force depolymerization

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Actin isoform

A

Alpha:most abundant-in muscle filament
Beta and gamma:somatic cell -hücre hareketlerinde düzenleyici protein
Alpha-sarcomeric actinin refers to actin binding protein not filament itself

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Microtubules

A

Energy type is GTP
Protein subunit:Tubulin protein
Pattern:hollow
Isoform: alpha-beta-gamma-delta-epsilon

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Microtubules

A

Alpha +beta=dimer
They form protofilament
13 filament=microtubule
Organize değil dağınık
GTP fosfat kaybedip GDP ye dönüşürse eksi yöne hareket eder
Dynamic instability: artı uçta çok fazla kararsızlık gösterirler

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Regulate microtubule

A

Tubulin concentration
Temperature

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Some specifics Microtubules

A

——Axonome
Cilium:hücre uzantısı
Flagellum: sperm kuyruğu dynein proteininden yapılmış
——Spindles:mitosis and meiosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Microtubule drugs

A

Colchicine:inhibit polymerization
Vincristin,vinblastin:inhibit polymerization
Nocodazole: induce polymerization
Paclitaxel: induce polymerization

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Mitotic Microtubules

A

All acetylated
Resistance for environmental toxin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Types of Intermediate filament

A

Subunit:lamin-nucleous=connected nuclear inner membrane
Keratin-epithelial
Fibroblast-vimentin=most abundant /mesencyme
Muscle cell-Desmin
Neurons-neurofilament
Pattern:fibrillary filament
Most durable and most stable filament
Peripherin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Alongation Intermediate filament

A

Artı eksi kutbu yok
Alpha helix monomer
Two filament =coiled- coil dimer
2 coiled-coil dimer=tetramer
2 tetramer+eight tetramer=rope like filament

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Associated proteins of cytoskeleton

A

Binding/regulatory:determination of length angle and number
—ABP:actin binding in microfilament
—MAP: microtubule associated in Microtubules akson boyunca bulunur
—IFBP: intermediate filament in intermediate filament
Motor proteins:intracellular transport,cytokinesis,contraction
—kinesin
—dynein
—myosin

17
Q

MAP-2 and tau

A

Microtubule play role in maintaining stability
Tau=Alzheimer disease

18
Q

Acting binding protein

A
19
Q

Disease related to cytoskeletal disorder

A

Cardiovascular syndrome
Neurodegenerate disease Parkinson
Cancer invasion
Liver cirrhosis
Pulmonary fibrosis
Blistered skin disease

20
Q

Bullous pemphigoid

A

Mast cell secreted:ECF eosinophil chemotactic factor
ECF cause secreted proteases
Proteases break down keratin filament in hemidesmosomes layer between epithelium and dermis
Araya vücut sıvısı girer

21
Q

Progeria sendromu

A

Nokta mutasyonu LMN A geni lamin filamenti sentezler

22
Q

Largerst to smallest

A

Microtubule intermediate filament microflament

23
Q

Diapedesis

A

Neutrophils use pseudopodia to crawl in or out of blood vessels

24
Q

Microtubules

A

Thickest and largest

25
Q

!!!!!

A

Sentromer kinetekor proteinleriyle kaplı

26
Q

Intermediateflament

A

Cell cell junction
Anchor

Modul2-week3 (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions